Rabbit Anti-APP Recombinant Antibody (VS3-FY2626) (CAT#: VS3-FY2626)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Amyloid beta precursor protein of human, mouse and rat origins

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB, IHC, ICC, IP

• Conjugate
• Unconjugated, FITC

• Related Disease
• Bone related disease

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Immunoprecipitation: 1/20
  Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100
  Immunocytochemistry: 1/50-1/200

• Alternative Names
• Amyloid Beta Precursor Protein; Amyloid Beta (A4) Precursor Protein; Alzheimer Disease Amyloid Protein; Cerebral Vascular Amyloid Peptide; Amyloid Precursor Protein; Peptidase Nexin-II; Protease Nexin-II; PreA4; PN-II; ABPP; APPI; CVAP; AD1; Beta-Amyloid Precursor Protein

• Gene ID
• 351

• UniProt ID
• P05067

• Sequence Similarities
• Belongs to the APP family.

• Cellular Localization
• Cell membrane; Single-pass type I membrane protein
  Membrane; Single-pass type I membrane protein
  Perikaryon
  Cell projection, growth cone
  Membrane, clathrin-coated pit
  Early endosome
  Cytoplasmic vesicle

• Post Translation Modifications
• Proteolytically processed under normal cellular conditions.
  Proteolytically cleaved by caspases during neuronal apoptosis.
  N-glycosylated
  Phosphorylation in the C-terminal on tyrosine, threonine and serine residues is neuron-specific
  Extracellular binding and reduction of copper, results in a corresponding oxidation of Cys-144 and Cys-158, and the formation of a disulfide bond.
  Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP).
  Amyloid-beta peptides are degraded by IDE.
  Sulfated on tyrosine residues.
  Glycosylation at Thr107, Thr381, Thr352, Thr353, Thr366, Thr367, Ser370, Thr371, Asn542, Asn571, Thr600, Thr633, Thr651, Thr652, Ser656, Thr659, Thr663, Ser667, and Tyr681
  Ubiquitination at Lys751 and Lys763
  Modification sites at PhosphoSitePlus
  Glycosylation from Gly
  Glycosylation from GlyGen 26 sites, 4 N-linked glycans (1 site), 5 O-linked glycans (22 sites)

• Protein Refseq
• NP_000475.1; NP_001129488.1; NP_001129601.1; NP_001129602.1; NP_001129603.1

• Function
• Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
  Interaction between APP molecules on neighboring cells promotes synaptogenesis.

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

• 2ND-057CQ
• Donkey Anti-Rabbit IgG (H&L) Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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