Human Anti-F8 Recombinant Antibody (VS-0524-YC29) (CAT#: VS-0524-YC29)

• Host Species
• Human

• Type
• Human IgG4

• Specificity
• Human and porcine factor VIII

• Species Reactivity
• Human, Porcine

• Applications
• ELISA, Neut

• Related Disease
• Hemophilia A and Thrombophilia, X-Linked, Due To Factor Viii Defect.

• Purification
• Protein A purified

• Purity
• >95%

• Buffer
• PBS, pH 7.4

• Preservative
• No preservative

• Storage
• Centrifuge briefly prior to opening vial. Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• IC₅₀ values of 5.2 nmol/L against porcine FVIII and IC₅₀ values of 2.89 nmol/L against human FVIII.

• Alternative Names
• Coagulation Factor VIII; Coagulation Factor VIII, Procoagulant Component; Antihemophilic Factor; F8C; AHF; Coagulation Factor VIII A1 Domain; Coagulation Factor VIII C2 Domain; Coagulation Factor VIIIc; Procoagulant Component;

• Gene ID
• 2157

• UniProt ID
• P00451

• Long Name
• Coagulation factor VIII
  (FVIII)

• Sequence Similarities
• Belongs to the multicopper oxidase family.

• Cellular Localization
• Secreted, extracellular space

• Post Translation Modifications
• Sulfation on Tyr-1699 is essential for binding vWF.
  Proteolytically cleaved by cathepsin CTSG to produce a partially activated form.
  Glycosylation at Asn60, Asn258, Asn601, Asn776, Asn803, Asn847, Asn919, Asn962, Asn982, Asn1020, Asn1024, Asn1074, Asn1085, Asn1204, Asn1274, Asn1278, Asn1301, Asn1319, Asn1431, Asn1461, Asn1829, and Asn2137.

• Function
• Acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.

Isotype Control

• MRO-A1584-YJ
• Human IgG4 kappa (S228P) Isotype Control

Secondary Antibody

• 2ND-024CQ
• Goat Anti-Human IgG (H&L) Antibody

• 2ND-025CQ
• Rabbit Anti-Human IgG (H&L) Antibody

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