Anti-PD-L1 Antibody-Cytokine Fusion Protein, IgG (PD1-AB1)-IFNL3 (CAT#: ACFP-CQ2849)

• Target
• PD-L1

• Molecule Class
• IgG-IFNL3

• Species Reactivity
• Human

• Expression Host
• CHO

• Clone
• PD1-AB1

• Cytokine 1
• IFNL3

• Cytokines 1 Description
• This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).

• Cytokine 1 Species
• Human

• Applications
• This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Introduction
• This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation.

• Alternative Names
• CD274; PD-L1; PDCD1L1; B7-H; Programmed Death Ligand 1; Programmed Cell Death 1 Ligand 1; PDCD1LG1; B7H1

• Gene ID
• 29126

• UniProt ID
• Q9NZQ7

• TAB-0190CL
• Anti-Human CD274 Recombinant Antibody (PD1-AB1)

• TAB-0190CL-S(P)
• Anti-Human CD274 Recombinant Antibody scFv Fragment (PD1-AB1)

• TAB-0190CL-F(E)
• Anti-Human CD274 Recombinant Antibody Fab Fragment (PD1-AB1)

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