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CD22 & saporin

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Anti-CD22 & saporin Recombinant Antibody Products

  • Anti-CD22 (clone 5E8)-SMCC-DM1 ADC (ADC-214CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone 7A2)-SMCC-DM1 ADC (ADC-215CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone 10F4v3)-SPP-DM1 ADC (ADC-193LZY)
    • Target: CD22
    • Linker: SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-CD22 (clone 10F4v3)-MCC-DM1 ADC (ADC-194LZY)
    • Target: CD22
    • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-CD22 (clone hu10F4)-MCC-DM1 ADC (ADC-027LZY)
    • Target: CD22
    • Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-CD22-mc-vc-PABc-MMAE ADC (ADC-033LZY)
    • Target: CD22
    • Linker: mc-VC-PABc(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
    • Drug: MMAE (monomethyl auristatin E)
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  • Anti-CD22-mc-vc-PABc-NMS249 ADC (ADC-097LZY)
    • Target: CD22
    • Linker: mc-VC-PABc (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
    • Drug: NMS249
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  • Anti-CD22-MC-MMAF ADC (ADC-032LCT)
    • Target: CD22
    • Linker: Mc (maleimidocaproyl)
    • Drug: MMAF (Monomethyl auristatin F)
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  • Anti-CD22-MCC-DM1 ADC (ADC-033LCT)
    • Target: CD22
    • Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (RFB4)-mcc-DM1 ADC (ADC-028LCT)
    • Target: CD22
    • Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone 10F4)-SMCC-DM1 ADC (ADC-223CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone RFB4)-SMCC-DM1 ADC (ADC-224CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone 10F4v1)-SMCC-DM1 ADC (ADC-216CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone 10F4v2)-SMCC-DM1 ADC (ADC-217CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone 10F4v3)-SMCC-DM1 ADC (ADC-219CL)
    • Target: CD22
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-CD22 (clone 10F4v3)-SPP-DM1 ADC (ADC-221CL)
    • Target: CD22
    • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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For Research Use Only. Not For Clinical Use.


CD22 is a B-cell-specific transmembrane glycoprotein belonging to the SIGLEC (sialic acid-binding immunoglobulin-like lectin) family. It is encoded by the CD22 gene located on chromosome 19q13.1. CD22 plays a crucial role in B-cell signaling and immune response modulation. It acts primarily as an inhibitory co-receptor that regulates B-cell receptor (BCR) signaling, thereby preventing overactivation of B cells and reducing the risk of autoimmunity. CD22 binds to sialylated glycans and recruits SHP-1 (Src homology region 2 domain-containing phosphatase-1), a phosphatase that dampens signaling cascades.
CD22 & saporin
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
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