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    HER2 & MET

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    Anti-HER2 & MET Products

    • Anti-Human Met(Onartuzumab) (TAB-190-F(E))
      • Derivation: Humanized (from mouse)
      • Species Reactivity: Human
      • Type: Fab / Fc - G1 - kappa
      • Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
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    For Research Use Only. Not For Clinical Use.


    Background

    HER2 is a protein encoded by the ERBB2 gene, and it is a member of the epidermal growth factor receptor (EGFR) family. It plays a crucial role in cell growth and differentiation. Overexpression or amplification of the HER2 gene is associated with several aggressive forms of cancer, most notably breast cancer. This overexpression leads to increased cell proliferation and tumor growth, making HER2 a significant target for cancer diagnostics and therapeutics. Monoclonal antibodies and small molecule inhibitors that target HER2 have significantly improved outcomes for patients with HER2-positive cancers.
    This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.
    HER2 & MET
    Related Diseases
    Breast Cancer Breast Cancer
    EGFR Tyrosine Kinase Inhibitor Resistance EGFR Tyrosine Kinase Inhibitor Resistance
    EGFR Tyrosine Kinase Inhibitor Resistance EGFR Tyrosine Kinase Inhibitor Resistance
    Endocrine Resistance Endocrine Resistance
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