What does antibody isotype mean?

Complement fixation and Fc receptor binding are two examples of how the isotype influences an antibody's effector function.

How can I increase the sensitivity of the test?

A more sensitive detection technique, an increase in antibody concentration, or improved test conditions can all be used.

What is meant by biotinylated antibodies?

Streptavidin-biotin interactions enable detection or enrichment of biotinylated antibodies due to their covalent biotin bond.

Mouse Anti-CD40 Recombinant Antibody (clone 2C5)

CAT#: HPAB-0264-YJ

This product is a recombinant mouse antibody that recognizes chicken CD40. It induces downstream CD40 signaling after binding to CD40.

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg

Normal Tissue Figure 2 Tonsil

Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40

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Specifications

Host Species
Mouse

Type
Mouse IgG

Specificity
Chicken

Species Reactivity
Chicken

Clone
2C5

Applications
ELISA, Agonist, FC

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

Application Notes
This antibody has been tested for use in Flow Cytometry.

Target

Alternative Names
p50; Bp50; CDW40; TNFRSF5; tumor necrosis factor receptor superfamily member 5; B cell surface antigen CD40; B cell-associated molecule; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor

Gene ID
958

UniProt ID
Q9DDD2

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Breast cancer biomarkers at key points during disease progression

Reproducible results

We've obtained highly reproducible results using this antibody product. It's played a critical role in several publications we've worked on.

Good value

For the price, this antibody product offers good value. The quality is comparable to more expensive brands we've used in the past.

Versatile application

We've used this antibody product in a variety of applications, from Western blotting to immunofluorescence, with consistently great results.

Q&As

What does antibody isotype mean?

A: Complement fixation and Fc receptor binding are two examples of how the isotype influences an antibody's effector function.
How can I increase the sensitivity of the test?

A: A more sensitive detection technique, an increase in antibody concentration, or improved test conditions can all be used.
What is meant by biotinylated antibodies?

A: Streptavidin-biotin interactions enable detection or enrichment of biotinylated antibodies due to their covalent biotin bond.

View the frequently asked questions answered by Creative Biolabs Support.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# HPAB-0264-YJ, RRID: AB_3111377)

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Related Diseases

Asthma

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Primary Immunodeficiency

Allograft Rejection

Autoimmune Thyroid Disease

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-0264-YJ.pdf

MSDS

MSDS - HPAB-0264-YJ.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "Clone 2C5"

CAT
Product Name

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HPAB-0162-YC-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-0162-YC-F(E))	FC	Human Fab
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HPAB-0165-YC-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-0165-YC-F(E))	FC	Human Fab
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NS-021CN	Human Anti-CD40 Recombinant Antibody (NS-021CN)	ELISA, IF, Block, FuncS	Human IgG
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NS-021CN-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (NS-021CN-S(P))	ELISA	Human scFv

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HPAB-M0479-YC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-M0479-YC-S(P))	ELISA, FC, FuncS	Human scFv
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CAT	Product Name	Application	Type
VS-0425-YC514	Recombinant Anti-CD40 Vesicular Antibody, EV Displayed (VS-0425-YC514)	ELISA, FC, Neut, Cell-uptake

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