Rabbit Anti-ERBB2 (pY1221/pY1222) Recombinant Antibody (clone R87-5Y-7)
CAT#: VS3-WK2090
This product is a rabbit recombinant antibody that is specific to phosphorylated ERBB2. The target of this antibody is phospho-ERBB2 (Tyr1221/Tyr1222). The clone R87-5Y-7 can be used in WB analysis at a dilution of 1/500-1/1000. The molecular weight of ERBB2 (pTyr1221/pTyr1222) observed in WB experiments using this antibody is 185 kDa.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1060/169_D12_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1338/if_selected.jpg
Normal Tissue
Figure 3 High expression in esophagus
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1383/4682_B_5_1_val_selected.jpg
Normal Tissue
Figure 4 IHC staining of human rectum
Immunohistochemical staining of human rectum shows weak cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/ihc_selected.jpg
Normal Tissue
Figure 5 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/ihc_selected.jpg
Normal Tissue
Figure 6 Kidney
Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/1054_A_7_5.jpg
Normal Tissue
Figure 7 Breast
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Myoepithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/45831_B_3_4.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (OE19, SK-BR-3)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141736-ERBB2
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Phospho-Tyr1221/Tyr1222 of human ERBB2
- Species Reactivity
- Human
- Clone
- R87-5Y-7
- Applications
- WB
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% Glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- Erb-B2 Receptor Tyrosine Kinase 2; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; Tyrosine Kinase-Type Cell Surface Receptor HER2; Neuro/Glioblastoma Derived Oncogene Homolog; Human Epidermal Growth Factor Receptor 2; Metastatic Lymph Node Gene 19 Protein; Proto-Oncogene C-ErbB-2; Proto-Oncogene Neu; EC 2.7.10.1; P185erbB2; MLN 19; HER2; NGL; NEU; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog)
- Gene ID
- 2064
- UniProt ID
- P04626
- Long Name
- Erb-B2 Receptor Tyrosine Kinase 2
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Related Diseases
Bladder Cancer
Non-small Cell Lung Cancer
Related Signaling Pathways
ErbB Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| TAB-049CT | Anti-Human HER2/neu Recombinant Antibody (ChA21) | IHC, Inhib, WB, Activ, FC | Chimeric antibody (mouse/human) |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| AGTO-G022D | Anti-ERBB2 immunotoxin 4D5 (scFv)-DT | Cytotoxicity assay, Function study | |
| AGTO-G022G | Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel | Cytotoxicity assay, Function study | |
| AGTO-G022R | Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA | Cytotoxicity assay, Function study | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-041 | Human Anti-ERBB2 Recombinant Antibody (clone bH1) | WB, IF, FuncS | Human IgG |
| MOB-0103MZ | Recombinant Mouse Anti-ERBB2 Antibody (clone C980M) | ELISA | Mouse antibody |
| MOB-014LC | Mouse Anti-ERBB2 Recombinant Antibody (MOB-014LC) | ELISA, FC | Mouse IgG |
| MOB-014LC-F(E) | Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (MOB-014LC-F(E)) | ELISA, FC | Mouse Fab |
| MOB-014LC-S(P) | Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (MOB-014LC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-089 | Mouse Anti-ERBB2 Recombinant Antibody (clone A21); scFv Fragment | ELISA, WB, FC | Mouse scFv |
| HPAB-0193-WJ-S(P) | Mouse Anti-ERBB2 Recombinant Antibody (clone 6H8); scFv Fragment | ELISA | Mouse scFv |
| HPAB-M0073-YC-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-M0073-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-M0074-YC-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-M0074-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-M0075-YC-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-M0075-YC-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-161 | Mouse Anti-ERBB2 Recombinant Antibody (clone chA21); scFv Fragment | FC, WB | Mouse scFv |
| FAMAB-0098-YC-F(E) | Mouse Anti-ERBB2 Recombinant Antibody (clone E402); Fab Fragment | Cyt | Mouse Fab |
| FAMAB-0099-YC-F(E) | Human Anti-ERBB2 Recombinant Antibody (clone CH402); Fab Fragment | Cyt | Human Fab |
| HPAB-M0073-YC-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-M0073-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-M0074-YC-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-M0074-YC-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0191CL | Human Anti-ERBB2 Recombinant Antibody (TAB-0191CL) | ELISA, Cyt, Internalization | Human IgG |
| TAB-0192CL | Human Anti-ERBB2 Recombinant Antibody (TAB-0192CL) | ELISA, ADCC, Cyt, Internalization | Human IgG |
| TAB-0193CL | Human Anti-ERBB2 Recombinant Antibody (TAB-0193CL) | ELISA, ADCC, Cyt, Internalization | Human IgG |
| PABX-081-F (E) | Recombinant Human Anti-HER2 Antibody Fab Fragment (Gr3 ) | WB, ELISA, FuncS | Fab |
| PABX-082-F (E) | Recombinant Human Anti-HER2 Antibody Fab Fragment (Gr6) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-033CT-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-033CT-F(E)) | ELISA, WB | Humanized Fab |
| TAB-038CT-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-038CT-F(E)) | WB | Humanized Fab |
| TAB-039CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (h1E11) | WB | Humanized antibody |
| TAB-041CT-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-041CT-F(E)) | ELISA, WB | Humanized Fab |
| TAB-050CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (HuA21) | ELISA, WB | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-032CT | Anti-Human HER2/neu Single Domain Antibody, Research Grade Biosimilar | WB | Single domain antibody |
| TAB-046CT | Anti-Human HER2/neu Single Domain Antibody (TAB-046CT), Research Grade Biosimilar | ELISA, Inhibition, FC | Single domain antibody |
| HPAB-0201-FY | Recombinant llama Anti-ERBB2 Antibody (HPAB-0201-FY) | E | llama VHH |
| HPAB-0202-FY | Recombinant llama Anti-ERBB2 Antibody (HPAB-0202-FY) | E | llama VHH |
| HPAB-0203-FY | Recombinant llama Anti-ERBB2 Antibody | IF | llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-024LC | Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-117LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-145LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-146LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-147LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-148LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-177LC | Recombinant Anti-Human ERBB2 Antibody (Non-glycosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0195MZ | Chicken Anti-ERBB2 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-737CQ | Mouse Anti-ERBB2 Recombinant Antibody (clone 7.16.4) | Block, IP, IF, FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1178 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone DS1178AB) | IHC-P, IHC-Fr | Rabbit IgG |
| MOR-4586 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH99DS) | WB | Rabbit IgG |
| MOR-4587 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH100DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3061 | PE-A*02:01/Human ERBB2 (CLTSTVQLV) MHC Tetramer | FCM | |
| MHC-CN0641 | PE-A*02:01/Human ERBB2 (LIAHNQVRQV) MHC Tetramer | FCM, IHC | |
| MHC-CN0642 | APC-A*02:01/Human ERBB2 (LIAHNQVRQV) MHC Tetramer | FCM, IHC | |
| MHC-CN0643 | FITC-A*02:01/Human ERBB2 (LIAHNQVRQV) MHC Tetramer | FCM, IHC | |
| MHC-CN0644 | A*02:01/Human ERBB2 (LIAHNQVRQV) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-468CQ | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-468CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-053 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-053) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-761 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-761) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-005 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-005) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY91 | AbPlus™ Anti-ERBB2 Magnetic Beads (3.F2) | IP, Protein Purification | |
| VS-0724-YC1516 | AbPlus™ Anti-Erbb2 Magnetic Beads (VS-0724-YC1516) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY24 | Human Anti-ERBB2 (clone 1.18.1) scFv-Fc Chimera | FC, BI | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY108 | CytoStream™ Mouse Anti-ERBB2 Recombinant Antibody (clone 24D2) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC430 | Recombinant Anti-ERBB2 Vesicular Antibody, EV Displayed (VS-0425-YC430) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2335 | Anti-ERBB2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2336 | Anti-Mouse ERBB2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC3 | Recombinant Anti-ERBB2 Biparatopic Antibody, Symmetric scFv-Fab | ELISA | Symmetric scFv-Fab |
| VS-0525-YC6 | Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero Fab | ELISA | Asymmetric hetero Fab |
| VS-0525-YC7 | Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero HC-LC | ELISA, Inhib | Asymmetric hetero HC, common LC |
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