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CD70

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
CD70
    • Target: CD70
    • Linker: mc-VC (maleimidocaproyl-valine-citrulline)
    • Drug: pyrrolobenzodiazepine (PBD) dimers
    • Target: CD70
    • Linker: VC (valine-citrulline)
    • Drug: AFP (auristatin phenylalanine phenylenediamine)
    • Target: CD70
    • Linker: VC (valine-citrulline)
    • Drug: AFP (auristatin phenylalanine phenylenediamine)

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