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EPCAM & CD3

Engineered Antibody Glyco-Abs MHC
EPCAM (Epithelial Cell Adhesion Molecule) is a carcinoma-associated antigen. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. Diseases associated with EPCAM include Diarrhea 5, With Tufting Enteropathy, Congenital and Colorectal Cancer, Hereditary Nonpolyposis, Type 8.
In immunology, the CD3 (cluster of differentiation 3) T-cell co-receptor is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. The TCR, ζ-chain, and CD3 molecules together comprise the TCR complex.

  • Anti-EpCAM-SPDB-DM4 ADC (ADC-100LZY)

    • Target: EpCAM
    • Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
    • Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)

  • Anti-EpCAM (B38.1)-SMCC-DM1 ADC (ADC-112LCT)

    • Target: EpCAM
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)

  • Anti-EpCAM-SMCC-DM1 ADC (ADC-099LZY)

    • Target: EpCAM
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)

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