DR5 & FAP
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
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- Targets: DR5 & FAP
- Type: Fab2
- Application: FuncS, Promising therapeutic agent
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- Class: Class I
- Antigen: FAP
- Antigen Species: Human
- Peptide: ALVCYGPGI
- Conjugate: Unconjugated
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- Class: Class I
- Antigen: FAP
- Antigen Species: Human
- Peptide: ALVCYGPGI
- Conjugate: FITC
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- Class: Class I
- Antigen: FAP
- Antigen Species: Human
- Peptide: ALVCYGPGI
- Conjugate: APC
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- Class: Class I
- Antigen: FAP
- Antigen Species: Human
- Peptide: ALVCYGPGI
- Conjugate: PE
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- Class: Class I
- Antigen: FAP
- Antigen Species: Human
- Peptide: GLFKCGIAV
- Conjugate: Unconjugated
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- Class: Class I
- Antigen: FAP
- Antigen Species: Human
- Peptide: GLFKCGIAV
- Conjugate: FITC
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- Class: Class I
- Antigen: FAP
- Antigen Species: Human
- Peptide: GLFKCGIAV
- Conjugate: APC
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- Class: Class I
- Antigen: FAP
- Antigen Species: Human
- Peptide: GLFKCGIAV
- Conjugate: PE
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- Class: Class I
- Antigen: FAP
- Antigen Species: Human
- Peptide: SDYYFSWL
- Conjugate: Unconjugated
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- Class: Class I
- Antigen: FAP
- Antigen Species: Human
- Peptide: SDYYFSWL
- Conjugate: FITC
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- Class: Class I
- Antigen: FAP
- Antigen Species: Human
- Peptide: SDYYFSWL
- Conjugate: APC
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- Class: Class I
- Antigen: FAP
- Antigen Species: Human
- Peptide: SDYYFSWL
- Conjugate: PE
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- Class: Class I
- Antigen: muFAP alpha
- Antigen Species: Human
- Peptide: SDYYFSWL
- Conjugate: Unlabeled, Biotin, R-PE, APC
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- Class: Class I
- Antigen: FAP alpha
- Antigen Species: Human
- Peptide: ALVCYGPGI
- Conjugate: Unlabeled, Biotin, R-PE, APC
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- Class: Class I
- Antigen: FAP
- Antigen Species: Human
- Peptide: GLFKCGIAV
- Conjugate: Unlabeled, Biotin, R-PE, APC
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC, ELISA
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- Species Reactivity: Human
- Type: Human scFv
- Application: FC, ELISA
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, FC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
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- Species Reactivity: Human
- Type: Human IgG1
- Application: RIA, FuncS, ELISA
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- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA
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- Species Reactivity: Human
- Type: Human IgG1
- Application: RIA, FuncS, ELISA
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- Species Reactivity: Human
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- Species Reactivity: Human
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, IF, IP
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- Species Reactivity: Human
- Type: Human IgG
- Application: FC, ELISA
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- Species Reactivity: Human
- Application: ELISA, WB, IHC, FuncS
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Species Reactivity: Human, Mouse, Monkey
- Type: Human Fab
- Application: ELISA, FC, IF
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- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: FC, ELISA
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- Species Reactivity: Human, Mouse, Monkey
- Type: Human scFv
- Application: ELISA, FC, IF
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- Species Reactivity: Human, Mouse
- Type: Human scFv
- Application: FC, ELISA
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- Species Reactivity: Human, Mouse, Monkey
- Type: Human IgG1
- Application: IHC, ELISA, FC, IF
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- Species Reactivity: Human, Mouse
- Type: Human IgG1
- Application: FC, ELISA
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, IP, FC, FuncS, Neut, IF, WB
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG1
- Application: ELISA, FC, IHC, IP, IF
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human, Mouse
- Type: Chimeric (mouse/human) IgG1, κ
- Application: ELISA, IHC
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- Species Reactivity: Human, Mouse
- Type: Human IgG1
- Application: ELISA, WB, FC, IHC, IP
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- Derivation: Humanized
- Species Reactivity: Human, Mouse
- Type: Humanized IgG1, κ
- Application: ELISA
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG2a
- Application: ELISA
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- Derivation: Phage display library
- Species Reactivity: Human, Mouse
- Type: Human IgG
- Application: ELISA, IF
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- Species Reactivity: Human, Mouse, Cynomolgus monkey
- Type: Human IgG1
- Application: SPR, IHC
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- Species Reactivity: Human, Mouse
- Type: Human IgG1
- Application: ELISA, Inhib, IHC, IF, FuncS
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- Species Reactivity: Human, Mouse
- Type: Human IgG1
- Application: FC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, FC, Inhib
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- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, IHC, FC, Inhib
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Glycosylation site: Fc region
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Glycosylation site: Fc region
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Glycosylation site: Fc region
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Glycosylation site: Fc region
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Glycosylation site: Fc region
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Glycosylation site: Fc region
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Glycosylation site: Fc region
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- Host Species: Human
- Specificity: Human
- Type: Human antibody
- Glycosylation site: Fc region
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- Target: FAP
- Species Reactivity: Human
- Cytokine 1: IL10
- Host: Human
- Cytokine 1 Species: Human
- Molecule Class: Fab-IL10
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- Target: FAP
- Species Reactivity: Human
- Cytokine 1: IL10
- Host: Human
- Cytokine 1 Species: Human
- Molecule Class: IgG1-IL10
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- Target: FAP
- Species Reactivity: Human
- Cytokine 1: IL10
- Host: Human
- Cytokine 1 Species: Human
- Molecule Class: Fab-IL10
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- Target: FAP
- Species Reactivity: Human
- Cytokine 1: IL10
- Host: Human
- Cytokine 1 Species: Human
- Molecule Class: IgG1-IL10
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: ELISA, IP, FC, FuncS, Neut, IF
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- Target: fibroblast activation proteinα
- Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Target: FAP
- Linker: AO-Mc-
- Drug: MMAE (Monomethyl auristatin E)
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- Target: FAP
- Linker: MC-PABC (maleimidocaproyl-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Target: FAP
- Linker: AO-Mc-
- Drug: MMAE (Monomethyl auristatin E)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, IHC, IP, IF
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- Species Reactivity: Human, Mouse
- Type: Human scFv
- Application: ELISA, WB, FC, IHC, IP
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- Derivation: Humanized
- Species Reactivity: Human, Mouse
- Type: Humanized scFv
- Application: ELISA
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- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: ELISA
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- Derivation: Phage display library
- Species Reactivity: Human, Mouse
- Type: Human scFv
- Application: ELISA, IF
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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- Species Reactivity: Human, Mouse
- Type: Human scFv
- Application: ELISA, Inhib, IHC, IF, FuncS
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- Species Reactivity: Human, Mouse
- Type: Human scFv
- Application: FC, ELISA, IF
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- Species Reactivity: Human, Mouse, Cynomolgus monkey
- Type: Human scFv
- Application: FC, ELISA, IF
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- Species Reactivity: Human, Mouse, Cynomolgus monkey
- Type: Human Fab
- Application: FC, ELISA, IF
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- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: FC, ELISA, IF
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- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: ELISA, Inhib, IHC, IF, FuncS
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: ELISA, FC, IHC, IP, IF
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human, Mouse
- Type: Chimeric (mouse/human) Fab
- Application: ELISA, IHC
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- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: ELISA, WB, FC, IHC, IP
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- Derivation: Humanized
- Species Reactivity: Human, Mouse
- Type: Humanized Fab
- Application: ELISA
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- Species Reactivity: Human, Mouse
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Phage display library
- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: ELISA, IF
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- Derivation: VHH phage display library
- Species Reactivity: Human
- Type: VHH
- Application: ELISA
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