Melanoma-associated proteoglycan & CD28

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For Research Use Only. Not For Clinical Use.


Background

CD28: Encodes a co-stimulatory receptor on T cells. It binds B7 ligands to enhance T-cell activation, proliferation, and survival. The protein is essential for adaptive immunity. Dysregulation impairs immune responses and tolerance.
Melanoma-associated proteoglycan & CD28
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.
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