Anti-Human CD3 Recombinant Antibody (TAB-159) (CAT#: TAB-159)
Recombinant monoclonal antibody to CD3. It is a monoclonal antibody which is used as an immunosuppressive drug. This is a humanized Fc-engineered monoclonal antibody also known as MGA031 and hOKT3γ1(Ala-Ala).
Specific Inquiry
ELISA
Figure 1 Anti-Human CD3 Antibody (TAB-159) in ELISA
ELISA analysis of TAB-159 was performed by coating with recombinant human CD3e protein (His Tag). Then blocked with BSA and incubated with TAB-159. The HRP-conjugated goat anti-human IgG as a secondary antibody (1:5000). Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
FC
Figure 2 Anti-Human CD3 Antibody (TAB-159) in FC
Flow cytometry analysis of Jurkat cells with purified antibody TAB-159 (Lot#CB2101Y13). Cells were blocked with Human TruStain FcXTM and washed with 0.5% BSA-PBS. An FITC-conjugated goat anti-human IgG secondary antibody was added.
PC: Positive Control, Blue (Biolegend, 317306)
Lot#CB2101Y13: CB2101Y13 batch, Blue (TAB-159)
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- Neut, ELISA, IF, IP, FuncS, FC, ICC
- MW
- 145.8 kDa
- Related Disease
- Type 1 diabetes
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The CD3D antibody has been reported in applications of FC, RT-PCR.
Target
- Alternative Names
- Teplizumab;876387-05-2;MGA031;hOKT3gamma1(Ala-Ala);CD3D;CD3d molecule, delta (CD3-TCR complex);CD3d antigen, delta polypeptide (TiT3 complex) , T3D;T-cell surface glycoprotein CD3 delta chain;CD3 delta;OKT3, delta chain;CD3 antigen, delta subunit;T-cell r
- Gene ID
- 915
- UniProt ID
- P04234
Related Resources
Please refer to Teplizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Teplizumab.
Primary Immunodeficiency
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0557 | Hi-Affi™ Rabbit Anti-CD3D Recombinant Antibody (clone DS557AB) | WB, IHC, ICC, IP | Rabbit IgG |
Customer Reviews and Q&As
Customer Review
Q&As
Michael White
Ideal for CD3 Research
Ideal for CD3 Research
The Anti-Human CD3 Therapeutic Antibody (Teplizumab) has been a fantastic addition to our CD3 studies. Its specificity and sensitivity are outstanding, consistently providing clear results. This antibody has become essential for our research, improving the accuracy and reliability of our assays.
07-Nov-23
Laura Scott
Reliable in Immunoassays
Reliable in Immunoassays
We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for CD3 is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.
11-Oct-22
Brian Young
Consistent and Effective
Consistent and Effective
This antibody has proven to be consistent and dependable in our assays. The high-quality, reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The strong affinity and specificity for CD3 have been particularly beneficial.
28-Jun-21
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-159, RRID: AB_3111841)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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