Anti-Human CD3 Recombinant Antibody (Teplizumab) (CAT#: TAB-159)
Recombinant monoclonal antibody to CD3. Teplizumab is a monoclonal antibody which is used as an immunosuppressive drug. Teplizumab is a humanized Fc-engineered monoclonal antibody also known as MGA031 and hOKT3γ1(Ala-Ala).
Specific Inquiry
Figure 1 Flow cytometry also demonstrates over-expression of T cell genes in rituximab-vs. placebo-treated subjects.
A Correlation of modular gene expression with cell subset levels determined by flow cytometry. Shown is a heatmap representation of the correlation between modular gene expression measured by RNA-seq vs. the percentages of cell subsets determined by flow cytometry. Gene expression was calculated as median log2 expression values in reads per million (RPM) + 1 for all genes in the indicated module. Cell subsets were determined by antibody staining and were expressed as percentages of total lymphocytes. The magnitude of Pearson's correlation coefficients (r) are represented by color intensity; Red, positive correlation; Blue, negative correlation. This plot was derived from 27 rituximab-treated subjects tested at week 26. b CD3+ and CD4+, but not CD8+ T cell subsets were transiently overexpressed in rituximab-treated subjects. Percentages of the indicated cell subsets for all subjects at all visits were normalized by z-scores ((value-mean of values)/SD of values). Shown are the z-score normalized mean percentages of the indicated cell subsets determined by flow cytometry vs. time of visit. There were 30–35 rituximab- vs. 14–17 placebo-treated subjects tested at weeks 0–104 for each marker; and 25, 4, and 2 rituximab- vs. 12, 2, and 1 placebo-treated subjects at weeks 128–176.
Linsley, P. S., Greenbaum, C. J., Rosasco, M., Presnell, S., Herold, K. C., & Dufort, M. J. (2018). Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes. Genes & Immunity, 1.
Figure 2 Schematic representation of the humanization strategy for CD3E, CD3D, and CD3G.
Representative results of RT-PCR analysis for mouse Cd3 edg or human CD3 EDG expression in the blood cells.
Ueda, O. , Wada, N. A. , Kinoshita, Y. , Hino, H. , Kakefuda, M. , & Ito, T. , et al. (2018). Corrigendum: entire cd3ε, δ, and γ humanized mouse to evaluate human cd3–mediated therapeutics. Scientific Reports, 8, 46960.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- Neut, ELISA, IF, IP, FuncS, FC, ICC
- CAS
- 876387-05-2
- Generic Name
- Teplizumab
- UNII
- S4M959U2IJ
- MW
- 145.8 kDa
- Related Disease
- Type 1 diabetes
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The CD3D antibody has been reported in applications of FC, RT-PCR.
Target
- Alternative Names
- Teplizumab;876387-05-2;MGA031;hOKT3gamma1(Ala-Ala);CD3D;CD3d molecule, delta (CD3-TCR complex);CD3d antigen, delta polypeptide (TiT3 complex) , T3D;T-cell surface glycoprotein CD3 delta chain;CD3 delta;OKT3, delta chain;CD3 antigen, delta subunit;T-cell r
- Gene ID
- 915
- UniProt ID
- P04234
Related Resources
Please refer to Teplizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Teplizumab.
Primary Immunodeficiency
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Teplizumab"
Afuco™ Anti-CD3D ADCC Recombinant Antibody (Teplizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD3. Teplizumab is a monoclonal antibody which is used as an immunosuppressive drug. Teplizumab is a humanized Fc-engineered monoclonal antibody also known as MGA031 and hOKT3γ1(Ala-Ala).
See other products for "CD3D"
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Recombinant Antibody
Rabbit Monoclonal Antibody
scFv Fragment Antibody
Fab Fragment Antibody
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1284z | Mouse Anti-CD3D Recombinant Antibody (clone 21C10) | WB, ELISA | Mouse IgG1 |
| HPAB-0381-FY | Human Anti-CD3D Recombinant Antibody (HPAB-0381-FY) | FC, ELISA | Human IgG |
| HPAB-0382-FY | Human Anti-CD3D Recombinant Antibody (HPAB-0382-FY) | Activ | Human lgA |
| HPAB-0384-FY | Rat Anti-CD3D Recombinant Antibody (HPAB-0384-FY) | ELISA | Rat IgG |
| VS3-WK1275 | Mouse Anti-CD3D Recombinant Antibody (clone AI504783) | ELISA, WB, IHC | Mouse IgG2a |
Customer Reviews and Q&As
Customer Review
Q&As
-
Ideal for CD3 Research
The Anti-Human CD3 Therapeutic Antibody (Teplizumab) has been a fantastic addition to our CD3 studies. Its specificity and sensitivity are outstanding, consistently providing clear results. This antibody has become essential for our research, improving the accuracy and reliability of our assays. -
Reliable in Immunoassays
We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for CD3 is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab. -
Consistent and Effective
This antibody has proven to be consistent and dependable in our assays. The high-quality, reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The strong affinity and specificity for CD3 have been particularly beneficial.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-159, RRID: AB_3111841)
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Application: WB, FuncS, IF, Neut, ELISA, FC, IP
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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