Obinutuzumab (CAT#: Gly-003CL)

Obinutuzumab is a humanized monoclonal antibody used as a combination treatment with chlorambucil to treat patients with untreated chronic lymphocytic leukemia. It was approved by the FDA in November 2013 and is marketed under the brand name Gazyva. There is a black box warning of fatal Hepatitis B Virus (HBV) reactivation and fatal Progressive Multifocal Leukoencephalopathy (PML).


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Subcellular Location and Protein Expression

Normal Tissue

RNA Expression


Specifications

  • Type
  • Biotech
  • Protein chemical formula
  • C6512H10060N1712O2020S44
  • Protein average weight
  • 146100.0 Da
  • CAS number
  • 949142-50-1
  • Class
  • Carboxylic Acids and Derivatives
  • Mechanism of action
  • In contrast to rituximab, which is a classic type I CD20 antibody, obinutuzumab binds to type II CD20 antibodies. This allows obinutuzumab to have a much higher induction of antibody-dependant cytotoxicity and a higher direct cytotoxic effect than the classic CD20 antibodies.

References

  • Synonyms
  • Afutuzumab

Downloads

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See other products for "MS4A1"

Chimeric Antibody

CAT Product Name Application Type
TAB-207 Anti-Human CD20 Recombinant Antibody ELISA, IP, FC, FuncS, Neut, IF, ICC IgG1 - kappa
TAB-1633CL-S(P) Anti-Human MS4A1 Recombinant Antibody scFv Fragment (ch1F5) FC Chimeric antibody (mouse/human)
TAB-1634CL-S(P) Anti-Human MS4A1 Recombinant Antibody scFv Fragment (ch1F5-DXL) FC, Apop, CDC, ADCC, Inhib Chimeric antibody (mouse/human)
TAB-1656CL-S(P) Anti-Human MS4A1 Recombinant Antibody scFv Fragment (ch2B8) FC, CMCD, ADCC, Activ, Inhib, Depletion Chimeric antibody (mouse/human)
PABX-026 Recombinant Human Anti-CD20 Antibody (C2H7) FuncS IgG

Recombinant Antibody

CAT Product Name Application Type
PABL-422 Human Anti-MS4A1 Recombinant Antibody (clone 2F2) WB, ELISA, FuncS Human IgG1,κ
PABL-423 Mouse Anti-MS4A1 Recombinant Antibody (clone GA101) FC, Activ, Agonist, IF, WB, Cyt, FuncS Mouse IgG
FAMAB-0241CQ Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7) ELISA, FC, IHC, IP Mouse IgG2b, κ
HPAB-0742-CN Human Anti-MS4A1 Recombinant Antibody (HPAB-0742-CN) ELISA, FC Human IgG
HPAB-0743-CN Human Anti-MS4A1 Recombinant Antibody (HPAB-0743-CN) ELISA, FC Human IgG

Fab Fragment Antibody

CAT Product Name Application Type
PFBL-419 Human Anti-MS4A1 Recombinant Antibody (clone 2F2); Fab Fragment WB, ELISA, FuncS Human Fab
PFBL-420 Mouse Anti-MS4A1 Recombinant Antibody (clone GA101); Fab Fragment WB, ELISA, FuncS Mouse Fab
FAMAB-0144-CN-F(E) Human Anti-MS4A1 Recombinant Antibody (clone C2B8); Fab Fragment WB, ELISA Chimeric (mouse/human) Fab
HPAB-0465LY-F(E) Mouse Anti-MS4A1 Recombinant Antibody (clone CBL004LY); Fab Fragment ELISA Mouse Fab
HPAB-0466LY-F(E) Mouse Anti-MS4A1 Recombinant Antibody (clone CBL005LY); Fab Fragment ELISA Mouse Fab

Mouse Antibody

CAT Product Name Application Type
TAB-1657CL Anti-Human MS4A1 Recombinant Antibody (1K1422) Apop, FuncS
TAB-1658CL Anti-Human MS4A1 Recombinant Antibody (1K1791) Apop, FuncS
TAB-1659CL Anti-Human MS4A1 Recombinant Antibody (1K0924) Apop, FuncS
TAB-1660CL Anti-Human MS4A1 Recombinant Antibody (1K1712) Apop, FuncS
TAB-1701CL-F(E) Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1701CL-F(E)) FuncS Mouse Fab

Humanized Antibody

CAT Product Name Application Type
TAB-1694CL Human Anti-MS4A1 Recombinant Antibody (TAB-1694CL) CDC Humanized IgG
TAB-1695CL Human Anti-MS4A1 Recombinant Antibody (TAB-1695CL) Cyt, ELISA, FuncS Humanized IgG
TAB-1696CL Human Anti-MS4A1 Recombinant Antibody (TAB-1696CL) Cyt, ELISA, FuncS Humanized IgG
TAB-1697CL Human Anti-MS4A1 Recombinant Antibody (TAB-1697CL) Cyt, ELISA, FuncS Humanized IgG
TAB-1698CL Human Anti-MS4A1 Recombinant Antibody (TAB-1698CL) Cyt, ELISA, FuncS Humanized IgG

Human Antibody

CAT Product Name Application Type
TAB-1703CL Human Anti-MS4A1 Recombinant Antibody (TAB-1703CL) FC, CDC, IP Human IgG1, κ
TAB-1704CL Human Anti-MS4A1 Recombinant Antibody (TAB-1704CL) IP Human IgG1, κ
TAB-1705CL Human Anti-MS4A1 Recombinant Antibody (TAB-1705CL) Cyt, FC, FuncS Human IgG3, κ
TAB-0001CL-S(P) Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-0001CL-S(P)) ELISA Human scFv
TAB-1693CL-F(E) Anti-MS4A1 Recombinant Antibody Fab Fragment ELISA

Low- or Non-fucosylated Oligosaccharide

CAT Product Name Application Type
Gly-063LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Chimeric antibody (mouse/human)
Gly-134LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody
Gly-135LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody
Gly-136LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody
Gly-137LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-097LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)
Gly-115LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) ELISA Humanized antibody
Gly-134LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody
Gly-135LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody
Gly-136LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody

Hyper-galactosylated

CAT Product Name Application Type
Gly-142LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated) ELISA Human antibody

High-mannose Glycoform

CAT Product Name Application Type
Gly-155LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) ELISA Humanized antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-171LC Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) ELISA Chimeric antibody (mouse/human)

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC066 A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer FCM
MHC-LC067 A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer FCM
MHC-LC068 A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer FCM
MHC-LC4347 PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer FCM

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1751CQ Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) Neut, FuncS Mouse IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2295 Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB) IHC-Fr, IHC-P Rabbit IgG
MOR-4024 Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS) FC Rabbit IgG

Single-domain Antibody

CAT Product Name Application Type
HPAB-M0704-YC Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD25) ELISA, FuncS Camelid VHH
HPAB-M0705-YC Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD16) ELISA Camelid VHH
HPAB-M0706-YC Camelid Anti-MS4A1 Recombinant Antibody (clone R3CD7) ELISA Camelid VHH
HPAB-M0707-YC Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD78) ELISA Camelid VHH
HPAB-M0708-YC Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD17) ELISA Camelid VHH

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-772 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocrelizumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-016 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Rituximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-028 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ofatumumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-207 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ublituximab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-771 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocaratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-1325-FY-F(E) Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1325-FY-F(E)) FC, ELISA Human Fab
HPAB-J0043-YC-S(P) Mouse Anti-MS4A1 Recombinant Antibody (clone 13.6E12); scFv Fragment ELISA, FC, FuncS Mouse scFv
HPAB-1883-FY-F(E) Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1883-FY-F(E)) ELISA Mouse Fab
HPAB-1885-FY-F(E) Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1885-FY-F(E)) ELISA, FC Human Fab
HPAB-1954-FY-S(P) Human Anti-MS4A1 Recombinant Antibody (clone BD31-7); scFv Fragment Cyt Humanized scFv

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
WBWestern Blot

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