Obinutuzumab (CAT#: Gly-003CL)
Obinutuzumab is a humanized monoclonal antibody used as a combination treatment with chlorambucil to treat patients with untreated chronic lymphocytic leukemia. It was approved by the FDA in November 2013 and is marketed under the brand name Gazyva. There is a black box warning of fatal Hepatitis B Virus (HBV) reactivation and fatal Progressive Multifocal Leukoencephalopathy (PML).
Specific Inquiry
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line REH
(Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg
(Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg
Normal Tissue
Figure 4 Colon
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg
(Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg
Figure 5 Bone marrow
(Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg
(Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg
Figure 6 Lymph node
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (Daudi, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1
Specifications
- Type
- Biotech
- Protein chemical formula
- C6512H10060N1712O2020S44
- Protein average weight
- 146100.0 Da
- CAS number
- 949142-50-1
- Class
- Carboxylic Acids and Derivatives
- Mechanism of action
- In contrast to rituximab, which is a classic type I CD20 antibody, obinutuzumab binds to type II CD20 antibodies. This allows obinutuzumab to have a much higher induction of antibody-dependant cytotoxicity and a higher direct cytotoxic effect than the classic CD20 antibodies.
References
- Synonyms
- Afutuzumab
Downloads
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See other products for "MS4A1"
Single-domain Antibody
| CAT | Product Name | Application | Type |
| NAB-913-sdAb | Recombinant Anti-human MS4A1 VHH Single Domain Antibody | IP, FC, ChiP, Neut | Llama VHH |
| HPAB-M0704-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD25) | ELISA, FuncS | Camelid VHH |
| HPAB-M0705-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD16) | ELISA | Camelid VHH |
| HPAB-M0706-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone R3CD7) | ELISA | Camelid VHH |
| HPAB-M0707-YC | Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD78) | ELISA | Camelid VHH |
Mouse Antibody
| CAT | Product Name | Application | Type |
| TAB-H27 | Anti-Human MS4A1 Recombinant Antibody (Epitumomab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG2a |
| TAB-H39 | Anti-Human MS4A1 Recombinant Antibody (Ibritumomab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | Mouse IgG1 - kappa |
| TAB-1632CL | Anti-Human MS4A1 Recombinant Antibody (1F5) | FC | |
| TAB-1657CL | Anti-Human MS4A1 Recombinant Antibody (1K1422) | Apop, FuncS | |
| TAB-1658CL | Anti-Human MS4A1 Recombinant Antibody (1K1791) | Apop, FuncS |
Recombinant Antibody
| CAT | Product Name | Application | Type |
| PABW-019 | Human Anti-MS4A1 Recombinant Antibody (clone C2H7) | WB, IF, FuncS | Chimeric (mouse/human) IgG |
| FAMAB-0241CQ | Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7) | ELISA, FC, IHC, IP | Mouse IgG2b, κ |
| HPAB-0819-CN | Human Anti-MS4A1 Recombinant Antibody (clone 1F5RKF12) | ELISA, FC | Humanized IgG |
| HPAB-0820-CN | Human Anti-MS4A1 Recombinant Antibody (clone RHAxRKF12) | ELISA, FC | Humanized IgG |
| HPAB-1693LY | Mouse Anti-MS4A1 Recombinant Antibody (clone B-Ly1) | Neut, FC, IHC-Fr, IHC-P, IP | Mouse IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
| PFBW-019 | Human Anti-MS4A1 Recombinant Antibody (clone C2H7); Fab Fragment | WB, IF, FuncS | Chimeric (mouse/human) IgG |
| PSBZ-143 | Mouse Anti-MS4A1 Recombinant Antibody (clone KM3575); scFv Fragment | WB | Mouse scFv |
| HPAB-0819-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone 1F5RKF12); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-0820-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone RHAxRKF12); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-1693LY-F(E) | Mouse Anti-MS4A1 Recombinant Antibody (clone B-Ly1); Fab Fragment | Neut, FC, IHC-Fr, IHC-P, IP | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
| TAB-1654CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1654CL) | FC, Apop | Human IgG1, κ |
| TAB-1655CL-S(P) | Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1655CL-S(P)) | ELISA | Human scFv |
| TAB-1674CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (101) | Cyt, ELISA, FuncS, Inhib | |
| TAB-1676CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1676CL-F(E)) | ELISA | Human Fab |
| TAB-1693CL-F(E) | Anti-MS4A1 Recombinant Antibody Fab Fragment | ELISA |
Humanized Antibody
| CAT | Product Name | Application | Type |
| TAB-1677CL | Anti-Human MS4A1 Recombinant Antibody (IBI-301) | PK | Humanized antibody |
| TAB-1694CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1694CL) | CDC | Humanized IgG |
| TAB-1695CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1695CL) | Cyt, ELISA, FuncS | Humanized IgG |
| TAB-1696CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1696CL) | Cyt, ELISA, FuncS | Humanized IgG |
| TAB-1697CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1697CL) | Cyt, ELISA, FuncS | Humanized IgG |
Chimeric Antibody
| CAT | Product Name | Application | Type |
| TAB-1633CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (ch1F5) | FC | Chimeric antibody (mouse/human) |
| TAB-1665CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1665CL-F(E)) | CDC | Chimeric (mouse/human) Fab |
| TAB-1666CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1666CL-F(E)) | CDC | Chimeric (mouse/human) Fab |
| TAB-1700CL-F(E) | Anti-Human MS4A1 Recombinant Antibody Fab Fragment (R92-3-1) | ADCC | Chimeric antibody (mouse/human) |
| PABX-026 | Recombinant Human Anti-CD20 Antibody (C2H7) | FuncS | IgG |
Fc Glycosylation
| CAT | Product Name | Application | Type |
| Gly-059LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| Gly-060LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-154LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-155LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Humanized antibody |
| Gly-158LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (mouse/human) |
Low- or Non-fucosylated Oligosaccharide
| CAT | Product Name | Application | Type |
| Gly-134LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-135LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-136LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-137LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-138LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Hyper-galactosylated
| CAT | Product Name | Application | Type |
| Gly-142LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA | Human antibody |
High-mannose Glycoform
| CAT | Product Name | Application | Type |
| Gly-155LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Humanized antibody |
Deglycosylated Antibody (Non-glycosylated IgGs)
| CAT | Product Name | Application | Type |
| Gly-171LC | Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) | ELISA | Chimeric antibody (mouse/human) |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
| MHC-LC066 | A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC067 | A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC068 | A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC4347 | PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer | FCM |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
| NEUT-1751CQ | Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) | Neut, FuncS | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
| MOR-2295 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB) | IHC-Fr, IHC-P | Rabbit IgG |
| MOR-4024 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS) | FC | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
| HPAB-0247-FY-S(P) | Human Anti-MS4A1 Recombinant Antibody (clone EM201); scFv Fragment | Inhib, ELISA | Humanized scFv |
| HPAB-1775-FY-F(E) | Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1775-FY-F(E)) | ELISA, Activ | Mouse Fab |
| HPAB-1776-FY-F(E) | Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1776-FY-F(E)) | ELISA, Activ | Mouse Fab |
| HPAB-1777-FY-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone 1.3.3); scFv Fragment | ELISA, Cyt | Human scFv |
| HPAB-1885-FY-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1885-FY-F(E)) | ELISA, FC | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
| AFC-TAB-772 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocrelizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-016 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Rituximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-028 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ofatumumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-207 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ublituximab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-771 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocaratuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
* Abbreviations
AgonistAgonist
BABioassay
InhibInhibition
PGProteogenomics
StimStimulation
WBWestern Blot
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