Obinutuzumab (CAT#: Gly-003CL)

Obinutuzumab is a humanized monoclonal antibody used as a combination treatment with chlorambucil to treat patients with untreated chronic lymphocytic leukemia. It was approved by the FDA in November 2013 and is marketed under the brand name Gazyva. There is a black box warning of fatal Hepatitis B Virus (HBV) reactivation and fatal Progressive Multifocal Leukoencephalopathy (PML).

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  • Datasheet
  • MSDS
  • COA

Specifications

  • Type
  • Biotech
  • Protein chemical formula
  • C6512H10060N1712O2020S44
  • Protein average weight
  • 146100.0 Da
  • CAS number
  • 949142-50-1
  • Class
  • Carboxylic Acids and Derivatives
  • Mechanism of action
  • In contrast to rituximab, which is a classic type I CD20 antibody, obinutuzumab binds to type II CD20 antibodies. This allows obinutuzumab to have a much higher induction of antibody-dependant cytotoxicity and a higher direct cytotoxic effect than the classic CD20 antibodies.

References

  • Synonyms
  • Afutuzumab

Downloads

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See other products for "MS4A1"

Single-domain Antibody

CAT Product Name Application Type
NAB-913-sdAb Recombinant Anti-human MS4A1 VHH Single Domain Antibody IP, FC, ChiP, Neut Llama VHH
HPAB-M0704-YC Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD25) ELISA, FuncS Camelid VHH
HPAB-M0705-YC Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD16) ELISA Camelid VHH
HPAB-M0706-YC Camelid Anti-MS4A1 Recombinant Antibody (clone R3CD7) ELISA Camelid VHH
HPAB-M0707-YC Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD78) ELISA Camelid VHH

Recombinant Antibody

CAT Product Name Application Type
PABZ-143 Human Anti-MS4A1 Recombinant Antibody (clone KM3575) WB Chimeric (mouse/human) IgG1, κ
MOB-027CQ Human Anti-MS4A1 Recombinant Antibody (clone CBLS-185) Neut, FuncS Human IgG1, κ
FAMAB-0241CQ Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7) ELISA, FC, IHC, IP Mouse IgG2b, κ
HPAB-0742-CN Human Anti-MS4A1 Recombinant Antibody (HPAB-0742-CN) ELISA, FC Human IgG
HPAB-0743-CN Human Anti-MS4A1 Recombinant Antibody (HPAB-0743-CN) ELISA, FC Human IgG

Humanized Antibody

CAT Product Name Application Type
TAB-1677CL Anti-Human MS4A1 Recombinant Antibody (IBI-301) PK Humanized antibody
TAB-1694CL Human Anti-MS4A1 Recombinant Antibody (TAB-1694CL) CDC Humanized IgG
TAB-1695CL Human Anti-MS4A1 Recombinant Antibody (TAB-1695CL) Cyt, ELISA, FuncS Humanized IgG
TAB-1696CL Human Anti-MS4A1 Recombinant Antibody (TAB-1696CL) Cyt, ELISA, FuncS Humanized IgG
TAB-1697CL Human Anti-MS4A1 Recombinant Antibody (TAB-1697CL) Cyt, ELISA, FuncS Humanized IgG

Mouse Antibody

CAT Product Name Application Type
TAB-1662CL-S(P) Anti-Human MS4A1 Recombinant Antibody scFv Fragment (1K1736) Apop, FuncS
TAB-1632CL-F(E) Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1F5) FC
TAB-1657CL-F(E) Anti-Human MS4A1 Recombinant Antibody Fab Fragment (1K1422) Apop, FuncS
TAB-1701CL-F(E) Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1701CL-F(E)) FuncS Mouse Fab
TAB-007ML Anti-Canine MS4A1 Recombinant Antibody (Blontuvetmab) ELISA, IHC, FC, IP, IF, FuncS IgG2, κ, λ

Chimeric Antibody

CAT Product Name Application Type
TAB-1665CL-S(P) Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1665CL-S(P)) CDC Mouse scFv
TAB-1666CL-S(P) Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1666CL-S(P)) CDC Mouse scFv
TAB-1667CL-S(P) Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1667CL-S(P)) CDC Mouse scFv
TAB-1668CL-S(P) Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1668CL-S(P)) CDC Mouse scFv
TAB-1669CL-S(P) Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1669CL-S(P)) CDC Mouse scFv

Human Antibody

CAT Product Name Application Type
TAB-1648CL-F(E) Anti-MS4A1 Recombinant Antibody Fab Fragment (MEDI-552) Inhib
TAB-1654CL-F(E) Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1654CL-F(E)) FC, Apop Human Fab
TAB-1655CL-F(E) Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1655CL-F(E)) ELISA Human Fab
TAB-1674CL-F(E) Anti-Human MS4A1 Recombinant Antibody Fab Fragment (101) Cyt, ELISA, FuncS, Inhib
TAB-1676CL-F(E) Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1676CL-F(E)) ELISA Human Fab

Fc Glycosylation

CAT Product Name Application Type
Gly-059LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)
Gly-060LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) ELISA Humanized antibody
Gly-062LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)
Gly-063LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Chimeric antibody (mouse/human)
Gly-067LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) ELISA, FC Chimeric antibody (mouse/human)

Low- or Non-fucosylated Oligosaccharide

CAT Product Name Application Type
Gly-134LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody
Gly-135LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody
Gly-136LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody
Gly-137LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody
Gly-138LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody

Hyper-galactosylated

CAT Product Name Application Type
Gly-142LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated) ELISA Human antibody

High-mannose Glycoform

CAT Product Name Application Type
Gly-155LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) ELISA Humanized antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-171LC Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) ELISA Chimeric antibody (mouse/human)

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC066 A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer FCM
MHC-LC067 A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer FCM
MHC-LC068 A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer FCM
MHC-LC4347 PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer FCM

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1751CQ Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) Neut, FuncS Mouse IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2295 Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB) IHC-Fr, IHC-P Rabbit IgG
MOR-4024 Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS) FC Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
FAMAB-0241CQ-S(P) Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7); scFv Fragment ELISA, FC, IHC, IP Mouse scFv
HPAB-0819-CN-S(P) Human Anti-MS4A1 Recombinant Antibody (clone 1F5RKF12); scFv Fragment ELISA, FC Humanized scFv
HPAB-1883-FY-F(E) Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1883-FY-F(E)) ELISA Mouse Fab
HPAB-1885-FY-F(E) Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1885-FY-F(E)) ELISA, FC Human Fab
HPAB-1954-FY-S(P) Human Anti-MS4A1 Recombinant Antibody (clone BD31-7); scFv Fragment Cyt Humanized scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0683-CN-F(E) Human Anti-MS4A1 Recombinant Antibody (clone Rmut8); Fab Fragment ELISA, FC Chimeric (mouse/human) Fab
HPAB-0684-CN-F(E) Human Anti-MS4A1 Recombinant Antibody (clone Rmut5); Fab Fragment ELISA, FC Chimeric (mouse/human) Fab
HPAB-0742-CN-F(E) Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0742-CN-F(E)) ELISA, FC Human Fab
HPAB-0743-CN-F(E) Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0743-CN-F(E)) ELISA, FC Human Fab
HPAB-0261CQ-F(E) Mouse Anti-MS4A1 Recombinant Antibody (clone CBM502); Fab Fragment ELISA, FC, FuncS Mouse Fab

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-772 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocrelizumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-016 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Rituximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-028 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ofatumumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-207 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ublituximab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-771 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocaratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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