Obinutuzumab (CAT#: Gly-003CL)

Obinutuzumab is a humanized monoclonal antibody used as a combination treatment with chlorambucil to treat patients with untreated chronic lymphocytic leukemia. It was approved by the FDA in November 2013 and is marketed under the brand name Gazyva. There is a black box warning of fatal Hepatitis B Virus (HBV) reactivation and fatal Progressive Multifocal Leukoencephalopathy (PML).


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Subcellular Location and Protein Expression

Normal Tissue

RNA Expression


Specifications

  • Type
  • Biotech
  • Protein chemical formula
  • C6512H10060N1712O2020S44
  • Protein average weight
  • 146100.0 Da
  • CAS number
  • 949142-50-1
  • Class
  • Carboxylic Acids and Derivatives
  • Mechanism of action
  • In contrast to rituximab, which is a classic type I CD20 antibody, obinutuzumab binds to type II CD20 antibodies. This allows obinutuzumab to have a much higher induction of antibody-dependant cytotoxicity and a higher direct cytotoxic effect than the classic CD20 antibodies.

References

  • Synonyms
  • Afutuzumab

Downloads

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See other products for "MS4A1"

Single-domain Antibody

CAT Product Name Application Type
NAB-913-sdAb Recombinant Anti-human MS4A1 VHH Single Domain Antibody IP, FC, ChiP, Neut Llama VHH
HPAB-M0704-YC Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD25) ELISA, FuncS Camelid VHH
HPAB-M0705-YC Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD16) ELISA Camelid VHH
HPAB-M0706-YC Camelid Anti-MS4A1 Recombinant Antibody (clone R3CD7) ELISA Camelid VHH
HPAB-M0707-YC Camelid Anti-MS4A1 Recombinant Antibody (clone 2HCD78) ELISA Camelid VHH

Mouse Antibody

CAT Product Name Application Type
TAB-H27 Anti-Human MS4A1 Recombinant Antibody (Epitumomab) IP, IF, FuncS, FC, Neut, ELISA, ICC IgG2a
TAB-H39 Anti-Human MS4A1 Recombinant Antibody (Ibritumomab) FC, IP, ELISA, Neut, FuncS, IF, ICC Mouse IgG1 - kappa
TAB-1632CL Anti-Human MS4A1 Recombinant Antibody (1F5) FC
TAB-1657CL Anti-Human MS4A1 Recombinant Antibody (1K1422) Apop, FuncS
TAB-1658CL Anti-Human MS4A1 Recombinant Antibody (1K1791) Apop, FuncS

Recombinant Antibody

CAT Product Name Application Type
PABW-019 Human Anti-MS4A1 Recombinant Antibody (clone C2H7) WB, IF, FuncS Chimeric (mouse/human) IgG
FAMAB-0241CQ Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7) ELISA, FC, IHC, IP Mouse IgG2b, κ
HPAB-0819-CN Human Anti-MS4A1 Recombinant Antibody (clone 1F5RKF12) ELISA, FC Humanized IgG
HPAB-0820-CN Human Anti-MS4A1 Recombinant Antibody (clone RHAxRKF12) ELISA, FC Humanized IgG
HPAB-1693LY Mouse Anti-MS4A1 Recombinant Antibody (clone B-Ly1) Neut, FC, IHC-Fr, IHC-P, IP Mouse IgG

Fab Fragment Antibody

CAT Product Name Application Type
PFBW-019 Human Anti-MS4A1 Recombinant Antibody (clone C2H7); Fab Fragment WB, IF, FuncS Chimeric (mouse/human) IgG
PSBZ-143 Mouse Anti-MS4A1 Recombinant Antibody (clone KM3575); scFv Fragment WB Mouse scFv
HPAB-0819-CN-F(E) Human Anti-MS4A1 Recombinant Antibody (clone 1F5RKF12); Fab Fragment ELISA, FC Humanized Fab
HPAB-0820-CN-F(E) Human Anti-MS4A1 Recombinant Antibody (clone RHAxRKF12); Fab Fragment ELISA, FC Humanized Fab
HPAB-1693LY-F(E) Mouse Anti-MS4A1 Recombinant Antibody (clone B-Ly1); Fab Fragment Neut, FC, IHC-Fr, IHC-P, IP Mouse Fab

Human Antibody

CAT Product Name Application Type
TAB-1654CL Human Anti-MS4A1 Recombinant Antibody (TAB-1654CL) FC, Apop Human IgG1, κ
TAB-1655CL-S(P) Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1655CL-S(P)) ELISA Human scFv
TAB-1674CL-F(E) Anti-Human MS4A1 Recombinant Antibody Fab Fragment (101) Cyt, ELISA, FuncS, Inhib
TAB-1676CL-F(E) Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1676CL-F(E)) ELISA Human Fab
TAB-1693CL-F(E) Anti-MS4A1 Recombinant Antibody Fab Fragment ELISA

Humanized Antibody

CAT Product Name Application Type
TAB-1677CL Anti-Human MS4A1 Recombinant Antibody (IBI-301) PK Humanized antibody
TAB-1694CL Human Anti-MS4A1 Recombinant Antibody (TAB-1694CL) CDC Humanized IgG
TAB-1695CL Human Anti-MS4A1 Recombinant Antibody (TAB-1695CL) Cyt, ELISA, FuncS Humanized IgG
TAB-1696CL Human Anti-MS4A1 Recombinant Antibody (TAB-1696CL) Cyt, ELISA, FuncS Humanized IgG
TAB-1697CL Human Anti-MS4A1 Recombinant Antibody (TAB-1697CL) Cyt, ELISA, FuncS Humanized IgG

Chimeric Antibody

CAT Product Name Application Type
TAB-1633CL-F(E) Anti-Human MS4A1 Recombinant Antibody Fab Fragment (ch1F5) FC Chimeric antibody (mouse/human)
TAB-1665CL-F(E) Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1665CL-F(E)) CDC Chimeric (mouse/human) Fab
TAB-1666CL-F(E) Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1666CL-F(E)) CDC Chimeric (mouse/human) Fab
TAB-1700CL-F(E) Anti-Human MS4A1 Recombinant Antibody Fab Fragment (R92-3-1) ADCC Chimeric antibody (mouse/human)
PABX-026 Recombinant Human Anti-CD20 Antibody (C2H7) FuncS IgG

Fc Glycosylation

CAT Product Name Application Type
Gly-059LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)
Gly-060LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) ELISA Humanized antibody
Gly-154LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) ELISA Humanized antibody
Gly-155LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) ELISA Humanized antibody
Gly-158LC Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Chimeric antibody (mouse/human)

Low- or Non-fucosylated Oligosaccharide

CAT Product Name Application Type
Gly-134LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody
Gly-135LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody
Gly-136LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody
Gly-137LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody
Gly-138LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) ELISA Humanized antibody

Hyper-galactosylated

CAT Product Name Application Type
Gly-142LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated) ELISA Human antibody

High-mannose Glycoform

CAT Product Name Application Type
Gly-155LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) ELISA Humanized antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-171LC Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) ELISA Chimeric antibody (mouse/human)

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC066 A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer FCM
MHC-LC067 A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer FCM
MHC-LC068 A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer FCM
MHC-LC4347 PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer FCM

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1751CQ Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) Neut, FuncS Mouse IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2295 Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB) IHC-Fr, IHC-P Rabbit IgG
MOR-4024 Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS) FC Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0247-FY-S(P) Human Anti-MS4A1 Recombinant Antibody (clone EM201); scFv Fragment Inhib, ELISA Humanized scFv
HPAB-1775-FY-F(E) Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1775-FY-F(E)) ELISA, Activ Mouse Fab
HPAB-1776-FY-F(E) Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1776-FY-F(E)) ELISA, Activ Mouse Fab
HPAB-1777-FY-F(E) Human Anti-MS4A1 Recombinant Antibody (clone 1.3.3); scFv Fragment ELISA, Cyt Human scFv
HPAB-1885-FY-F(E) Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1885-FY-F(E)) ELISA, FC Human Fab

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-772 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocrelizumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-016 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Rituximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-028 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ofatumumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-207 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ublituximab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-771 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocaratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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