Obinutuzumab (CAT#: Gly-003CL)

Obinutuzumab is a humanized monoclonal antibody used as a combination treatment with chlorambucil to treat patients with untreated chronic lymphocytic leukemia. It was approved by the FDA in November 2013 and is marketed under the brand name Gazyva. There is a black box warning of fatal Hepatitis B Virus (HBV) reactivation and fatal Progressive Multifocal Leukoencephalopathy (PML).

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  • Gene Expression
  • Datasheet
  • MSDS
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Type
  • Biotech
  • Protein chemical formula
  • C6512H10060N1712O2020S44
  • Protein average weight
  • 146100.0 Da
  • CAS number
  • 949142-50-1
  • Class
  • Carboxylic Acids and Derivatives
  • Mechanism of action
  • In contrast to rituximab, which is a classic type I CD20 antibody, obinutuzumab binds to type II CD20 antibodies. This allows obinutuzumab to have a much higher induction of antibody-dependant cytotoxicity and a higher direct cytotoxic effect than the classic CD20 antibodies.

References

  • Synonyms
  • Afutuzumab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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