Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-017)

Name: Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-017)
SKU: AFC-TAB-017
Rating: 5 (1 reviews)

CAT#: AFC-TAB-017

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human CD20. It is an IgG2a anti-CD20 monoclonal antibody derived from immortalized mouse cells.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line REH

Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg

Normal Tissue Figure 4 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg

Normal Tissue Figure 5 Bone marrow

Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (Daudi, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Mouse

Derivation
Mouse

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
Neut, ELISA, IF, IP, FuncS, FC

Conjugate
Unconjugated

Trade name
Bexxar

Generic Name
Tositumomab

Related Disease
Non-Hodgkin's lymphoma (NHL) (follicular, CD20 positive, following chemotherapy relapse)

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; CD20; B-lymphocyte antigen CD20; B1; Bp35; MS4A2; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1; S7; CVID5; LEU-16

Gene ID
931

UniProt ID
P11836

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Biosimilar Overview

Please refer to Tositumomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tositumomab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-017.pdf

MSDS

MSDS - AFC-TAB-017.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Tositumomab"

DrugMonitor™ Anti-Tositumomab Antibody (VS-1224-YC1229)
Tositumomab is an anti-CD20 monoclonal antibody used for B-cell non-Hodgkin's lymphoma treatment, conjugated with a radioactive isotope. The DrugMonitor™ Anti-Tositumomab Antibody (VS-1224-YC1229) is an anti-drug antibody (ADA) against Tositumomab. This drug-based antibody is raised in mice immunized with the Tositumomab. The anti-Tositumomab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Tositumomab in samples.

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CAT	Product Name	Application	Type
TAB-772	Human Anti-MS4A1 Recombinant Antibody (TAB-772)	ELISA, IP, FC, FuncS, Neut, IF, ICC	IgG1
TAB-771	Humanized Anti-MS4A1 Recombinant Antibody (TAB-771)	IF, IP, Neut, FuncS, ELISA, FC, ICC	Humanized IgG1, κ
TAB-1635CL	Anti-Human MS4A1 Recombinant Antibody (BVX20)	Inhib	Humanized antibody
TAB-1636CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1636CL)	ADCC, CDC	Humanized IgG
TAB-1637CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1637CL)	ADCC, CDC	Humanized IgG

CAT	Product Name	Application	Type
TAB-017	Anti-Human CD20 Recombinant Antibody (TAB-017)	Neut, ELISA, IF, IP, FuncS, FC, ICC	IgG2a - lambda
TAB-711	Anti-MS4A1 Recombinant Antibody (Technetium (99MTC) Nofetumomab Merpentan)	FC, IP, ELISA, Neut, FuncS, IF, ICC	Fab - G2b - kappa
TAB-001	Anti-Human CD20 Recombinant Antibody (Ibritumomab)	ELISA, IP, FC, FuncS, IF, Neut	IgG1 - kappa
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CAT	Product Name	Application	Type
PFBW-019	Human Anti-MS4A1 Recombinant Antibody (clone C2H7); Fab Fragment	WB, IF, FuncS	Chimeric (mouse/human) IgG
HPAB-0465LY-F(E)	Mouse Anti-MS4A1 Recombinant Antibody (clone CBL004LY); Fab Fragment	ELISA	Mouse Fab
HPAB-0466LY-F(E)	Mouse Anti-MS4A1 Recombinant Antibody (clone CBL005LY); Fab Fragment	ELISA	Mouse Fab
HPAB-1321-FY-S(P)	Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-1321-FY-S(P))	FC, ELISA	Human scFv
HPAB-1322-FY-S(P)	Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-1322-FY-S(P))	FC, ELISA	Human scFv

CAT	Product Name	Application	Type
TAB-0001CL	Human Anti-MS4A1 Recombinant Antibody (TAB-0001CL)	ELISA, ADCC, CDC	Human IgG
TAB-1648CL-F(E)	Anti-MS4A1 Recombinant Antibody Fab Fragment (MEDI-552)	Inhib
TAB-1654CL-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1654CL-F(E))	FC, Apop	Human Fab
TAB-1655CL-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1655CL-F(E))	ELISA	Human Fab
PABX-028-F (E)	Recombinant Human Anti-CD20 Antibody Fab Fragment (PABX-028-F (E))	WB, ELISA, IF, FuncS	Fab

CAT	Product Name	Application	Type
TAB-1670CL-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1670CL-F(E))	CDC	Chimeric (mouse/human) Fab
TAB-1671CL-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1671CL-F(E))	CDC	Chimeric (mouse/human) Fab
TAB-1675CL-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1675CL-F(E))	ELISA, WB	Chimeric (mouse/human) Fab
TAB-1692CL-F(E)	Anti-Human MS4A1 Recombinant Antibody Fab Fragment (Zytux)	ELISA, WB	Chimeric antibody (mouse/human)
TAB-1700CL-F(E)	Anti-Human MS4A1 Recombinant Antibody Fab Fragment (R92-3-1)	ADCC	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
Gly-059LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Chimeric antibody (mouse/human)
Gly-063LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)
Gly-097LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Chimeric antibody (mouse/human)
Gly-115LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Humanized antibody
Gly-138LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-063LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)
Gly-134LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-135LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-136LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-158LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
Gly-142LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-155LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-171LC	Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application
MHC-LC066	PE-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
MHC-LC067	APC-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
MHC-LC068	BV421-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
MHC-LC4347	PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer	FCM

CAT	Product Name	Application	Type
NEUT-1751CQ	Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211)	Neut, FuncS	Mouse IgG1, κ

CAT	Product Name	Application	Type
MOR-2295	Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB)	IHC-Fr, IHC-P	Rabbit IgG
MOR-4024	Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS)	FC	Rabbit IgG

CAT	Product Name	Application	Type
FAMAB-0241CQ	Mouse Anti-MS4A1 Recombinant Antibody (clone 2H7)	ELISA, FC, IHC, IP	Mouse IgG2b, κ
FAMAB-0144-CN	Human Anti-MS4A1 Recombinant Antibody (clone C2B8)	WB, ELISA	Chimeric (mouse/human) IgG1
HPAB-0742-CN	Human Anti-MS4A1 Recombinant Antibody (HPAB-0742-CN)	ELISA, FC	Human IgG
HPAB-0743-CN	Human Anti-MS4A1 Recombinant Antibody (HPAB-0743-CN)	ELISA, FC	Human IgG
HPAB-0744-CN	Human Anti-MS4A1 Recombinant Antibody (HPAB-0744-CN)	ELISA, FC	Human IgG

CAT	Product Name	Application	Type
HPAB-0683-CN-S(P)	Human Anti-MS4A1 Recombinant Antibody (clone Rmut8); scFv Fragment	ELISA, FC	Mouse scFv
HPAB-0684-CN-S(P)	Human Anti-MS4A1 Recombinant Antibody (clone Rmut5); scFv Fragment	ELISA, FC	Mouse scFv
HPAB-0742-CN-S(P)	Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-0742-CN-S(P))	ELISA, FC	Human scFv
HPAB-0743-CN-S(P)	Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-0743-CN-S(P))	ELISA, FC	Human scFv
HPAB-0744-CN-S(P)	Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-0744-CN-S(P))	ELISA, FC	Human scFv

CAT	Product Name	Application	Type
HPAB-M0704-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0704-YC)	ELISA, FuncS	Camelid VHH
HPAB-M0705-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0705-YC)	ELISA	Camelid VHH
HPAB-M0706-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0706-YC)	ELISA	Camelid VHH
HPAB-M0707-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0707-YC)	ELISA	Camelid VHH
HPAB-M0708-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0708-YC)	ELISA	Camelid VHH

CAT	Product Name	Application	Type
AFC-TAB-772	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-772)	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody
AFC-TAB-016	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-016)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-028	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-028)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody
AFC-TAB-207	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-207)	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody
AFC-TAB-771	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-771)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0424-XY188	AbPlus™ Anti-MS4A1 Magnetic Beads (VS-0424-XY188)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0924-YC138	Human Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC138), CDC Enhanced	FC, CDC, IP	Antibody hexamer
VS-0924-YC139	Mouse Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC139), CDC Enhanced	FC, Activ, Agonist, IF, WB, Cyt, CDC	Antibody hexamer

CAT	Product Name	Application	Type
VS-1024-XY85	Mouse Anti-NHP MS4A1 Recombinant Antibody (VS-1024-XY85)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0125-FY30	Human Anti-MS4A1 (clone RW005) scFv-Fc Chimera	FuncS	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY168	CytoStream™ Rat Anti-MS4A1 Recombinant Antibody (clone GOT214A)	FC	Rat IgG2a, kappa

CAT	Product Name	Application	Type
VS-0425-YC513	Recombinant Anti-MS4A1 Vesicular Antibody, EV Displayed (VS-0425-YC513)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY4510	Anti-MS4A1 Immunohistochemistry Kit	IHC
VS-0525-XY4511	Anti-Mouse MS4A1 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC129	Recombinant Anti-MS4A1 (Bin I x Bin II) Biparatopic Antibody, Tandem scFv	ELISA, FC	Tandem scFv
VS-0525-YC222	Recombinant Anti-MS4A1 Biparatopic Antibody, Tandem scFv	ELISA, IF, WB	Tandem scFv

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