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Charge Pair Bispecific Antibody (BsAb)

As a world-renowned biotech company, Creative Biolabs provides charge pair bispecific antibody generation services. With the unique charge pair platform, our talented scientists can develop novel and best-in-class bispecific antibodies for diverse therapeutic applications.

Diagram of a charge pair bispecific antibody Figure: Diagram of a charge pair bispecific antibody (J Mol Biol, 2012).

To overcome the heavy chain-pairing problem within bispecific antibody production, we selectively mutate the interface residues to construct light chain-heavy chain (LC-HC) pairs via charge pair technique (also called electrostatic steering strategy). Even when heavy chains and light chains originate from two distinct antibodies are co-expressed in one cell, this approach is still able to produce desired heterodimers efficiently by correct pairing immunoglubin chains. Charge pair bispecific antibody provided by Creative Biolabs possesses comparable high affinity against antigens as its parental antibodies. It would be an ideal tool for your academic or clinical studies. In addition, by this approach, trace amount of homodimer contaminants can appear, which further guarantee the quality of its final product.

Creative Biolabs offers customers pure and functional bispecific antibodies through charge pair platform for variant therapeutic applications. For more information, please contact us. Our highly-skilled and dedicated scientists are very glad to hear from you.


  1. Pavel Strop, et al. Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair. J Mol Biol. 2012 Jul 13;420(3):204-19.

For research use only. Not intended for any clinical use.

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