To meet the increasing requirements for recombinant antibodies from customers, Creative Biolabs has established a new platform for recombinant antibody services based on strand-exchange engineered domains (SEED) platform, which can provide custom SEEDbody services to accelerate your programs progress.

Figure: Diagram of SEEDbody (Protein Eng Des Sel, 2010)

Based on SEED technique, we have developed a strategy for the generation of asymmetric and bispecific antibodies which enlarge the therapeutic application of natural antibodies. SEED method is designed to regulate H-chain heterodimerization so as to generate heterodimer preferentially via sequence exchanging between IgG1 and IgA. All of our antibody engineering services are guaranteed and deliverable to satisfy your needs. As a world class biotech company, Creative Biolabs can provide high quality antibody engineering services with quick progressing time and rational price.

Key features of our bispecific antibody based on SEED platform:

  1. In vitro and in vivo stability
  2. Favorable pharmacokinetics
  3. High affinity
  4. Antibody-dependent cell-mediated cytotoxicity
  5. Complement-dependent cytotoxicity

Jonathan H. Davis, et al. SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fcanalogue platform for asymmetric binders or immunofusions and bispecific antibodies. Protein Eng Des Sel. 2010 Apr;23(4):195-202.

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