EPCAM & CD28
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized V-kappa
- Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
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- Anti-Human CD28 Recombinant Antibody (TGN1412) (TAB-064LC)
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC, Stim
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1
- Application: FC, IHC, FuncS, Inhib, Cyt
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG1, κ
- Application: ELISA, FuncS
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- Anti-Human EPCAM Recombinant Antibody (3-171) (TAB-356MZ)
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: Cyt, ELISA, FC, WB
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- Anti-Human EPCAM Recombinant Antibody (7-F17) (TAB-357MZ)
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Anti-Human EPCAM Recombinant Antibody (12-C15) (TAB-358MZ)
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Anti-Human EPCAM Recombinant Antibody (16-G5) (TAB-359MZ)
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Anti-Human EPCAM Recombinant Antibody (17-C20) (TAB-360MZ)
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Anti-Human EPCAM Recombinant Antibody (24-G6) (TAB-361MZ)
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Anti-Human CD28 Recombinant Antibody scFv Fragment (TGN1412) (TAB-064LC-S(P))
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC
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- Anti-Human EPCAM Recombinant Antibody scFv Fragment (3-171) (TAB-356MZ-S(P))
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Anti-Human EPCAM Recombinant Antibody scFv Fragment (7-F17) (TAB-357MZ-S(P))
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Anti-Human EPCAM Recombinant Antibody scFv Fragment (12-C15) (TAB-358MZ-S(P))
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Anti-Human EPCAM Recombinant Antibody scFv Fragment (16-G5) (TAB-359MZ-S(P))
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Anti-Human EPCAM Recombinant Antibody Fab Fragment (3-171) (TAB-356MZ-F(E))
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Anti-Human EPCAM Recombinant Antibody Fab Fragment (7-F17) (TAB-357MZ-F(E))
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Anti-Human EPCAM Recombinant Antibody Fab Fragment (12-C15) (TAB-358MZ-F(E))
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Anti-Human EPCAM Recombinant Antibody Fab Fragment (16-G5) (TAB-359MZ-F(E))
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Anti-Human EPCAM Recombinant Antibody Fab Fragment (17-C20) (TAB-360MZ-F(E))
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Anti-Human EPCAM Recombinant Antibody Fab Fragment (24-G6) (TAB-361MZ-F(E))
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Anti-Human EPCAM Recombinant Antibody Fab Fragment (3622W94) (TAB-362MZ-F(E))
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- Type: Humanized antibody
- Application: Confocal, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, FC, IHC, IP, FuncS
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Humanized (from mouse) IgG1
- Application: WB, Neut, ELISA, IF, IP, FuncS, FC
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- Human Anti-CD28 Recombinant Antibody; scFv Fragment (TAB-065LC-S(P)) (TAB-065LC-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Human Anti-CD28 Recombinant Antibody; scFv Fragment (TAB-066LC-S(P)) (TAB-066LC-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Anti-Human CD28 Recombinant Antibody scFv Fragment (ChTN228) (TAB-068LC-S(P))
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: FC, ELISA
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- Anti-Human CD28 Recombinant Antibody scFv Fragment (HuTN228) (TAB-069LC-S(P))
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC, ELISA
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- Human Anti-CD28 Recombinant Antibody (TAB-065LC) (TAB-065LC)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG, κ
- Application: ELISA
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- Mouse Anti-CD28 Recombinant Antibody (clone DD29.1) (MOB-0354MZ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Fab - G1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
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- Derivation: Human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: ELISA, IP, FC, FuncS, Neut
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: Neut, ELISA, IF, IP, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: ELISA, IP, FC, FuncS, IF, Neut
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- Rabbit Anti-EPCAM Polyclonal Antibody (MRO-1842-CN) (MRO-1842-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Species Reactivity: Human, Non-Human Primates
- Type: Mouse IgG1
- Application: FC, IP, WB, IHC, FuncS
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- Mouse Anti-CD28 Recombinant Antibody; scFv Fragment (HPAB-0245-FY-S(P)) (HPAB-0245-FY-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, IP, IF, FC
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- Mouse Anti-CD28 Recombinant Antibody; scFv Fragment (HPAB-0246-FY-S(P)) (HPAB-0246-FY-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC, FuncS, ICC, IHC, IP, WB
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- Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2216LY-F(E)) (HPAB-2216LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2217LY-F(E)) (HPAB-2217LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2218LY-F(E)) (HPAB-2218LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Mouse Anti-CD28 Recombinant Antibody (clone AV7); Fab Fragment (FAMAB-0013-CN-F(E))
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- Species Reactivity: Chicken, Turkey
- Type: Mouse Fab
- Application: FC
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- Human Anti-EPCAM Recombinant Antibody (clone HuMAB UBS-54); scFv Fragment (HPAB-0163CQ-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, FC, FuncS
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: L Kappa; PEGylated IgG4-IL2
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: GM-CSF
- Host: Human
- Cytokine 1 Species: Human
- Molecule Class: GM-CSF-FAB
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: scIL12
- Host: Mouse
- Cytokine 1 Species: Mouse
- Molecule Class: IgG1-scIL12
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: scIL12
- Host: Mouse
- Cytokine 1 Species: Mouse
- Molecule Class: scIL12-IgG1
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: TNFα
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: L Kappa; IgG4-(Deleted Lys)-TNFα
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- Target: CD28
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: IL2-IgG2a
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- Target: CD28
- Species Reactivity: Human
- Cytokine 1: TNF
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: TNF-IgG2a
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: L Kappa; IgG4-ala-IL2 (D20T)
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: IgG1-IL12-IL2
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: IgG1-scIL12-IL2
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Cytokine 2 Species: Human
- Molecule Class: IL12-IgG1-IL2
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
- Molecule Class: IL12-IgG1-IL2
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: scIL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
- Molecule Class: IgG1-scIL12-IL2
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: scIL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
- Molecule Class: scIL12-IgG1-IL2
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Humanized from Mouse
- Cytokine 1 Species: Mouse
- Molecule Class: L Kappa; IgG2a-IL12
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Human
- Cytokine 1 Species: Human
- Molecule Class: scFv-IL12
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: L Kappa; IgG4 (LSLS-ATAT)-IL2
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: L Kappa; IgG4 (N to Q)-IL2
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- Anti-Human EPCAM Recombinant Antibody scFv Fragment (HE2) (TAB-0531CL-S(P))
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- Application: ELISA, Inhib
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- Anti-Human EPCAM Recombinant Antibody Fab Fragment (HE2) (TAB-0531CL-F(E))
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- Application: ELISA, Inhib
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- Anti-Human EPCAM Recombinant Antibody (1G10) (TAB-368MZ)
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- Application: FC, ELISA
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- Anti-Human EPCAM Recombinant Antibody (12H8) (TAB-369MZ)
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- Application: FC, ELISA
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- Anti-Human EPCAM Recombinant Antibody (1F10) (TAB-370MZ)
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- Application: FC, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG2a - kappa
- Application: ELISA, IP, FC, FuncS, IF, Neut
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: IgG4 (S to P)-IL2
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (D20T)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: L Kappa; dI-IgG4-ala-IL2 (D20T)
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: IgG1-IL12
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Cytokine 2 Species: Human
- Molecule Class: IgG1-IL12-IL2
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (D20T)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: L Kappa; dI-IgG4 (FN>AQ)-ala-IL2 (D20T)
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (D20T)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: L Kappa; De-glycosylated dI-IgG4-ala-IL2 (D20T)
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (N88R)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: L Kappa; IgG4-ala-IL2 (N88R)
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (TTSR)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: L Kappa; IgG4-M1-IL2 (TTSR)
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- Anti-Human EPCAM Recombinant Antibody (HE2) (TAB-0531CL)
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- Application: ELISA, Inhib
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- anti-EPCAM immunotoxin MOC31 (IgG)-PE (AGTO-L013E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- anti-EPCAM immunotoxin MOC31 (IgG)-DT (AGTO-L013D)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- anti-EPCAM immunotoxin MOC31 (IgG)-Gel (AGTO-L013G)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- anti-EPCAM immunotoxin MOC31 (IgG)-RTA (AGTO-L013R)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin (AGTO-L013O)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Mouse Anti-EPCAM Recombinant Antibody; Fab Fragment (TAB-363MZ-F(E)) (TAB-363MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: Confocal, ELISA
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- Anti-EpCAM (B38.1)-Mal-dPEG4-NHS-DM1 ADC (ADC-111LCT)
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- Target: EpCAM
- Linker: PEG4Mal
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Anti-EpCAM (B38.1)-SMCC-DM1 ADC (ADC-112LCT)
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- Target: EpCAM
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Anti-EpCAM-SMCC-DM1 ADC (ADC-099LZY)
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- Target: EpCAM
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Anti-EpCAM-SPDB-DM4 ADC (ADC-100LZY)
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- Target: EpCAM
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Anti-EpCAM-sulfo-SPDB-DM4 ADC (ADC-101LZY)
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- Target: EpCAM
- Linker: sulfo-SPDB(sulfo-N-succinimidyl 4-(2-pyridyldithio)butyrate
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Anti-EpCAM (clone MOC31)-hydrazone-Doxorubicin ADC (ADC-149LZY)
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- Target: EpCAM
- Linker: acid-cleavable hydrazone
linker - Drug: Doxorubicin
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Background
CD28: Encodes a co-stimulatory receptor on T cells. It binds B7 ligands to enhance T-cell activation, proliferation, and survival. The protein is essential for adaptive immunity. Dysregulation impairs immune responses and tolerance.
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young