EPCAM & CD28
CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include Mycosis Fungoides and Sezary's Disease. Among its related pathways are Th2 Differentiation Pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and SH3/SH2 adaptor activity. An important paralog of this gene is CTLA4.
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
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- Targets: EPCAM & CD28
- Type: Fab2
- Application: FuncS, Promising therapeutic agent
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- Species Reactivity: Human, Non-Human Primates
- Type: Mouse IgG1
- Application: FC, IP, WB, IHC, FuncS
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- Derivation: Mouse
- Species Reactivity: canine
- Type: Mouse IgG1
- Application: WB, ELISA, FuncS
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- Derivation: Mouse
- Species Reactivity: Canine
- Type: Mouse scFv
- Application: WB, ELISA, FuncS
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- Derivation: Mouse
- Species Reactivity: canine
- Type: Mouse Fab
- Application: WB, ELISA, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, FC, IHC, IP, FuncS
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- Species Reactivity: Human
- Type: Mouse IgG1 F(ab')2, κ
- Application: Agonist, Stim, Neu, FC
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (D20T)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Cytokine 2: GM-CSF
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL4
- Cytokine 2: GM-CSF
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC, ELISA
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL4
- Cytokine 2: GM-CSF
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FuncS
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: FC, ELISA
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL4
- Cytokine 2: GM-CSF
- Host: Mouse
- Cytokine 1 Species: Human
- Cytokine 2 Species: Human
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: scIL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: FC, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: scIL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Cytokine 2 Species: Human
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA, FC
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG1
- Application: FC, IF, ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Mouse
- Cytokine 2 Species: Mouse
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- Species Reactivity: Monkey
- Type: Human antibody
- Application: Cyt, ELISA, FC, WB
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG, κ
- Application: ELISA
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Cytokine 2 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: TNFα
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Derivation: Humanized
- Type: Humanized antibody
- Application: FC, Stim
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Cytokine 2: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Cytokine 2 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: scIL12
- Host: Mouse
- Cytokine 1 Species: Mouse
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Mouse
- Cytokine 1 Species: Mouse
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- Application: ELISA, Inhib
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: scIL12
- Host: Mouse
- Cytokine 1 Species: Mouse
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Mouse
- Cytokine 1 Species: Human
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- Application: ELISA, Inhib
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (TTSR)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Mouse
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (N88R)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Application: ELISA, Inhib
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (D20T)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2 (D20T)
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Human
- Cytokine 1 Species: Mouse
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- Target: CD28
- Species Reactivity: Human
- Cytokine 1: TNF
- Host: Mouse
- Cytokine 1 Species: Human
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Application: Cyt, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized V-kappa
- Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Fab - G1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1
- Application: FC, IHC, FuncS, Inhib, Cyt
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG2a - kappa
- Application: ELISA, IP, FC, FuncS, IF, Neut
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Humanized (from mouse) IgG1
- Application: WB, Neut, ELISA, IF, IP, FuncS, FC
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Human
- Cytokine 1 Species: Human
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- Target: CD28
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
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- Target: EpCAM
- Linker: sulfo-SPDB(sulfo-N-succinimidyl 4-(2-pyridyldithio)butyrate
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: IL12
- Host: Humanized from Mouse
- Cytokine 1 Species: Mouse
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- Target: EpCAM
- Species Reactivity: Human
- Cytokine 1: GM-CSF
- Host: Human
- Cytokine 1 Species: Human
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Target: EpCAM
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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- Target: EpCAM
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Target: EpCAM
- Linker: acid-cleavable hydrazone
linker
- Drug: Doxorubicin
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Target: EpCAM
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Target: EpCAM
- Linker: PEG4Mal
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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