Magic™ Chlamydomonas reinhardtii Expression Service

The Magic™ Chlamydomonas reinhardtii Expression Service of Creative Biolabs has sophisticatedly designed an extraordinary protein expression service with multiple unparalleled advantages among conventional expression systems, especially for therapeutic antibodies and other high-value polypeptides for various basic research purposes and multiple health-care applications of Homo sapiens and other organisms. During decade’s accumulation, our service has specifically designed a series of strategies reaching the highest productivity and bioactivity with the whole spectrum of commercial improvements. There is no doubt that our creative service stands firmly at the scientific frontline of recombinant bioproduction.

The Introduction and Application of Chlamydomonas reinhardtii Expression

Since several creative researchers illustrated the incomparable merits of microalgae Chlamydomonas reinhardtii, our scientists at Creative Biolabs have dedicated to digging out the full potential of this tiny unbelievable organism to satisfy the most demanding requirements of commercial operation. As an ideal host for large-scale production of cutting-edge biopharmaceuticals currently, the extraordinary C. reinhardtii is manifested as a great biofactory possessing several simple characteristics with tremendous convenience and significance. Start with the most critical safety feature, this micro-producer is recognized as the generally regarded as safe (GRAS) for either consumption or health care of human and animals. Considering the basic requirements of expression host, C. reinhardtii grows robust enough with solar power and minimal nutrient medium.

Advantages of Magic™ Chlamydomonas reinhardtii Expression Service

1. Over 10 % accumulation of product with excellent bioactivity.
2. Systematic tools composed of several suitable vector systems and fabulous strains for varied purposes.
3. Optimal cultivation and induction with the whole range of scales from 5 mL to 1000 L per batch.
4. One-stop service: from initial design and optimization all the way down to purification and further modification with well recorded data and organized report.

For many years, the creative researchers and our service have developed this tiny organism to express protein vaccines, therapeutic antibodies, industrial enzymes, and other novel peptides successfully with almost 10 % accumulation, especially several the most valuable biopharmaceuticals. For instance, the first human therapeutic single-chain antibody and a full-length human monoclonal antibody were achieved manifesting the same binding affinity and a significantly greater yield under much lower expenditure than the traditional CHO system. Further extending has applied on the mammalian-gut mucin stimulant, mammary-associated serum amyloid protein (M-SAA), etc. Dedicated to perfecting this unbelievable natural gift, our service of Creative Biolabs has further created and optimized every single procedure of the whole technology. Without a doubt, we have the most professional team to design the best strategy for every particular target. No matter the initial selection and screen of the most suitable expression elements, or the downstream cultivation and purification, the Magic™ Chlamydomonas reinhardtii Expression Service offers the first-rate services in the world.

Creative Biolabs is dedicated to offering the best service with numerous cutting-edge technologies for superior expression of every single potential biopharmaceutical. Winging up with our aids, researcher may achieve the most creative and revolutionary product to rewrite the scientific history. If you have any question, contact us without hesitation.

References

1. Mayfield, Stephen P., and Scott E. Franklin. "Expression of human antibodies in eukaryotic micro-algae." Vaccine 23.15 (2005): 1828-1832.
2. Barrera, Daniel J., and Stephen P. Mayfield. "High-value Recombinant Protein Production in Microalgae." Handbook of Microalgal Culture: Applied Phycology and Biotechnology, Second Edition (2013): 532-544.
3. Hawkins, Richard L., and Michi Nakamura. "Expression of human growth hormone by the eukaryotic alga, Chlorella." Current Microbiology 38.6 (1999): 335-341.

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For research use only. Not intended for any clinical use.