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    EPCAM & CD28

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    Anti-EPCAM & CD28 ProductsBackground

    Anti-EPCAM & CD28 Products

    • Anti-EpCAM (B38.1)-SMCC-DM1 ADC (ADC-112LCT)
      • Target: EpCAM
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-EpCAM-SMCC-DM1 ADC (ADC-099LZY)
      • Target: EpCAM
      • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-EpCAM-SPDB-DM4 ADC (ADC-100LZY)
      • Target: EpCAM
      • Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
      • Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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    • Anti-EpCAM-sulfo-SPDB-DM4 ADC (ADC-101LZY)
      • Target: EpCAM
      • Linker: sulfo-SPDB(sulfo-N-succinimidyl 4-(2-pyridyldithio)butyrate
      • Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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    Background

    CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include Mycosis Fungoides and Sezary's Disease. Among its related pathways are Th2 Differentiation Pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and SH3/SH2 adaptor activity. An important paralog of this gene is CTLA4.
    EPCAM & CD28
    Edrecolomab is a mouse-derived monoclonal antibody targeting the cell-surface glycoprotein EpCAM/17-1A.
    Related Diseases
    Rheumatoid Arthritis Rheumatoid Arthritis
    Systemic Lupus Erythematosus Systemic Lupus Erythematosus
    Allograft Rejection Allograft Rejection
    Autoimmune Thyroid Disease Autoimmune Thyroid Disease
    Graft-versus-Host Disease Graft-versus-Host Disease
    Maturity Onset Diabetes of the Young Maturity Onset Diabetes of the Young
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