Anti-Human TNF alpha Recombinant Antibody Fab Fragment (Certolizumab Pegol) (CAT#: TAB-034-F(E))

Recombinant antibody Fragment Fab to TNF alpha. Certolizumab pegol is a monoclonal antibody directed against tumor necrosis factor alpha. More precisely, it is a PEGylated Fab' fragment of a humanized TNF inhibitor monoclonal antibody. Polyethylene glycol does not cross the placenta, so it should be safe in pregnancy.

Host: Mouse

Isotype: Fab'

Applications: ELISA, FC, IP, FuncS, IF, Neut, IHC, Activ, Inhib


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Activ

Figure 1 Efficacy variables in the certolizumab pegol (CZP) intention-to-treat (ITT) (n = 492) and week-24 CZP completer populations (n = 342).

a Mean disease activity score in 28 joints (erythrocyte sedimentation rate) (DAS28(ESR)). b Mean health assessment questionnaire-disability index (HAQ-DI). c American College of Rheumatologists (ACR)20 response. d ACR50 and ACR70 responses. For patients who withdrew at week 16, observed data from the week-12 visit was also included in the week-24 data (start of open-label extension). MMRM mixed model repeated measures, NRI non-responder imputation.

Smolen, J. S., van Vollenhoven, R., Kavanaugh, A., Strand, V., Vencovsky, J., Schiff, M.,... & Carter, D. (2015). Certolizumab pegol plus methotrexate 5-year results from the rheumatoid arthritis prevention of structural damage (RAPID) 2 randomized controlled trial and long-term extension in rheumatoid arthritis patients. Arthritis research & therapy, 17(1), 245.

Activ

Figure 2 Efficacy variables in patients following dose reduction from certolizumab pegol (CZP) 400 mg every 2 weeks (Q2W) to CZP 200 mg Q2W (n = 369).

a Mean disease activity score in 8 joints (erythrocyte sedimentation rate) (DAS28(ESR)). bAmerican College of Rheumatology (ACR)20 response rates. c ACR50 and ACR70 response rates. This analysis is presented as weeks following dose-reduction visit (Week 0 is defined as the final efficacy assessment visit where a patient received the CZP 400 mg dose).

Smolen, J. S., van Vollenhoven, R., Kavanaugh, A., Strand, V., Vencovsky, J., Schiff, M.,... & Carter, D. (2015). Certolizumab pegol plus methotrexate 5-year results from the rheumatoid arthritis prevention of structural damage (RAPID) 2 randomized controlled trial and long-term extension in rheumatoid arthritis patients. Arthritis research & therapy, 17(1), 245.

Inhib

Figure 3 Effect of CZP in patients with and without prior TNF inhibitor exposure at week 24 in terms of ACR response and the kinetics of ACR response.

CZP, Certolizumab pegol; Q2W, every 2 weeks; Q4W, every 4 weeks; PBO, placebo; TNF, tumour necrosis factor. (A) Percentages of patients with and without prior TNF inhibitor exposure achieving a response according to the American College of Rheumatology Criteria for 20% improvement (ACR20), 50% improvement (ACR50), and 70% improvement (ACR70) at week 24, by treatment group. (B) Percentages of patients with prior TNF inhibitor exposure achieving an ACR20, ACR50, and ACR70 response over time, by treatment group. (C) Percentages of patients without prior TNF inhibitor exposure achieving an ACR20, ACR50 and ACR70 response over time, by treatment group; *p<0.001; †p<0.05 versus placebo.

Mease, P. J., Fleischmann, R., Deodhar, A. A., Wollenhaupt, J., Khraishi, M., Kielar, D.,... & Van Der Heijde, D. (2014). Effect of certolizumab pegol on signs and symptoms in patients with psoriatic arthritis: 24-week results of a Phase 3 double-blind randomised placebo-controlled study (RAPID-PsA). Annals of the rheumatic diseases, 73(1), 48-55.

FuncS

Figure 4 Emotional Function and Systemic Symptoms were the domains that patients reported as being most improved by certolizumab pegol treatment.

Mean change from baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) domain scores during 12 weeks subcutaneous treatment with either certolizumab pegol or placebo in patients with moderate-to-severe Crohn's disease (intent-to-treat population); least-squares means (adjusted for stratum, pooled country, and baseline score): a Bowel Symptoms domain, b Systemic Symptoms domain, c Emotional Function domain, and d Social Function domain.

Rutgeerts, P., Schreiber, S., Feagan, B., Keininger, D. L., O’Neil, L., & Fedorak, R. N. (2008). Certolizumab pegol, a monthly subcutaneously administered Fc-free anti-TNFα, improves health-related quality of life in patients with moderate to severe Crohn’s disease. International journal of colorectal disease, 23(3), 289-296.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Mouse
  • Derivation
  • Humanized (from mouse)
  • Type
  • Fab'
  • Specificity
  • Tested positive against native human antigen.
  • Species Reactivity
  • Human
  • Applications
  • ELISA, FC, IP, FuncS, IF, Neut, IHC, Activ, Inhib
  • Trade name
  • cimzia
  • CAS
  • 428863-50-7
  • Generic Name
  • Certolizumab pegol
  • ATC Code
  • L04AB05
  • ChEMBL
  • CHEMBL1201831
  • MW
  • 47.75 kDa
  • Related Disease
  • Psoriatic arthritis (PSA)

Product Property

  • Purity
  • >95.0% as determined by analysis by SDS-PAGE.
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

  • Application Notes
  • The TNF antibody has been reported in applications of ELISA, FC, IP, FuncS, IF, Neut, IHC, Activ, Inhib.

Target

  • Alternative Names
  • Certolizumab pegol;cimzia;428863-50-7;CDP870;PHA-738144;TNF;tumor necrosis factor;TNFA, tumor necrosis factor (TNF superfamily, member 2);DIF;TNF superfamily;member 2;TNF alpha;TNFSF2;TNF-a;cachectin;APC1 protein;TNF, monocyte-derived;TNF, macrophage-deri

Related Resources

  • Biosimilar Overview
  • Related Diseases
  • Related Signaling Pathways
Please refer to Certolizumab Pegol Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Certolizumab Pegol.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "TNF"

Single-domain Antibody

CAT Product Name Application Type
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HPAB-AP531-YC Camel Anti-TNF Recombinant Antibody (HPAB-AP531-YC) ELISA Camel VHH
HPAB-AP532-YC Camel Anti-TNF Recombinant Antibody (HPAB-AP532-YC) ELISA Camel VHH
HPAB-AP533-YC Camel Anti-TNF Recombinant Antibody (HPAB-AP533-YC) ELISA Camel VHH
HPAB-AP534-YC Camel Anti-TNF Recombinant Antibody (HPAB-AP534-YC) ELISA Camel VHH

Mouse Antibody

CAT Product Name Application Type
TAB-768 Anti-TNF alpha Recombinant Antibody (Nerelimomab) FuncS, IF, Neut, ELISA, FC, IP, ICC IgG1
TAB-112CQ-F(E) Anti-Human TNF Recombinant Antibody Fab Fragment (A10G10) ELISA, WB
TAB-116CQ-F(E) Anti-Human TNF Recombinant Antibody Fab Fragment (Vh5/Vk12) ELISA
TAB-117CQ-F(E) Anti-Human TNF Recombinant Antibody Fab Fragment (TSK114) ELISA
TAB-123CQ-F(E) Mouse Anti-TNF Recombinant Antibody; Fab Fragment (TAB-123CQ-F(E)) ELISA, Neut Mouse Fab

Rat Antibody

CAT Product Name Application Type
TAB-623CL Bovine Anti-TNF Recombinant Antibody (TAB-623CL) Neut Bovine IgG

Fab Fragment Antibody

CAT Product Name Application Type
PFBL-349 Human Anti-TNF Recombinant Antibody (clone A2); Fab Fragment WB, ELISA, FuncS Human Fab
HPAB-0151-YC-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0151-YC-F(E)) ELISA, Inhib, FuncS Human Fab
HPAB-0046-FY-F(E) Mouse Anti-TNF Recombinant Antibody (clone 1B7); Fab Fragment Neut Mouse Fab
HPAB-2679LY-F(E) Mouse Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-2679LY-F(E)) ELISA Mouse Fab
HPAB-2680LY-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-2680LY-F(E)) FC, ELISA Humanized Fab

Humanized Antibody

CAT Product Name Application Type
TAB-110CQ Anti-Human TNF Recombinant Antibody (CDP571) ELISA Humanized antibody
TAB-114CQ Human Anti-TNF Recombinant Antibody (TAB-114CQ) ELISA, FC, Inhib Humanized antibody
TAB-115CQ Human Anti-TNF Recombinant Antibody (TAB-115CQ) ELISA, FC, Neut Humanized antibody
TAB-118CQ Anti-Human TNF Recombinant Antibody (YHB1411-2) FC, ELISA Humanized antibody
TAB-124CQ Human Anti-TNF Recombinant Antibody (TAB-124CQ) FuncS, Neut Humanized antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-148CQ Anti-Human TNF Recombinant Antibody ELISA Chimeric antibody (mouse/human)
TAB-402CQ Human Anti-TNF Recombinant Antibody (TAB-402CQ) ELISA Chimeric (mouse/human) IgG
TAB-148CQ-S(P) Anti-Human TNF Recombinant Antibody scFv Fragment ELISA Chimeric antibody (mouse/human)
TAB-148CQ-F(E) Anti-Human TNF Recombinant Antibody Fab Fragment ELISA Chimeric antibody (mouse/human)
TAB-402CQ-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-402CQ-F(E)) ELISA Chimeric (mouse/human) Fab

Human Antibody

CAT Product Name Application Type
TAB-406CQ-S(P) Anti-Human TNF Recombinant Antibody scFv Fragment (GB232) ELISA Human antibody
TAB-111CQ-F(E) Anti-Human TNF Recombinant Antibody Fab Fragment (B5) ELISA, WB Human antibody
TAB-113CQ-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-113CQ-F(E)) ELISA Human Fab
TAB-119CQ-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-119CQ-F(E)) ELISA, BL Human Fab
TAB-120CQ-F(E) Anti-Human TNF Recombinant Antibody Fab Fragment (IB-SA2n) ELISA, Neut Human antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-083LC Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) ELISA, FC Human antibody
Gly-098LC Recombinant Anti-Human TNF Antibody (Fc glycosylation) ELISA Human antibody
Gly-099LC Recombinant Anti-Human TNF Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)
Gly-100LC Recombinant Anti-Human TNF Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)
Gly-163LC Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) ELISA Chimeric antibody (mouse/human)

Non-hyper Galactosylated

CAT Product Name Application Type
Gly-083LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) ELISA, FC Human antibody

Sialylated IgG Glycan

CAT Product Name Application Type
Gly-085LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) ELISA, FC Human antibody
Gly-163LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) ELISA Chimeric antibody (mouse/human)

Hyper-galactosylated

CAT Product Name Application Type
Gly-086LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) ELISA, FC Human antibody
Gly-087LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) ELISA, FC Human antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0609MZ Chicken Anti-Tumor Necrosis Factor-α Polyclonal IgY Indirect ELISA, WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-2057CQ Rat Anti-Tnf Recombinant Antibody (clone XT3) Block, ELISA, IHC, WB Rat IgG1
NEUT-2070CQ Mouse Anti-TNF Recombinant Antibody (clone 4F4) Block, ELISA, ICC, IF, IHC, WB Mouse IgG1
NEUT-2071CQ Rabbit Anti-TNF Recombinant Antibody (clone 6E10) Block, ELISA, IHC, WB Rabbit IgG1
NEUT-2082CQ Mouse Anti-TNF Recombinant Antibody (clone B-C7) Block Mouse IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-2103CQ Mouse Anti-TNF Recombinant Antibody (clone CBL413) Neut Mouse IgG1
NEUT-2104CQ Rabbit Anti-TNF Recombinant Antibody (clone CBL1004) Neut Rabbit IgG
NEUT-2105CQ Mouse Anti-TNF Recombinant Antibody (clone MM0N1) Neut Mouse IgG1
NEUT-2106CQ Mouse Anti-TNF Recombinant Antibody (clone CBL1023) Neut Mouse IgG1
NEUT-2107CQ Mouse Anti-TNF Recombinant Antibody (clone TNF104C) WB, FuncS, ELISA, FC, Neut Mouse IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4460 Rabbit Anti-TNF Recombinant Antibody (clone SI554DS) ELISA Rabbit IgG
MOR-4461 Rabbit Anti-TNF Recombinant Antibody (clone SI555DS) Neut Rabbit IgG
MOR-4462 Rabbit Anti-TNF Recombinant Antibody (clone SI556DS) FC Rabbit IgG
MOR-4463 Rabbit Anti-TNF Recombinant Antibody (clone SI557DS) FC Rabbit IgG
MOR-4464 Rabbit Anti-TNF Recombinant Antibody (clone SI558DS) FC Rabbit IgG

Recombinant Antibody

CAT Product Name Application Type
HPAB-0151-YC Human Anti-TNF Recombinant Antibody (HPAB-0151-YC) ELISA, Inhib, FuncS Human IgG
HPAB-0675-CN Human Anti-TNF Recombinant Antibody (HPAB-0675-CN) ELISA, Neut Humanized IgG
HPAB-0676-CN Human Anti-TNF Recombinant Antibody (HPAB-0676-CN) ELISA, Neut Humanized IgG
HPAB-0677-CN Human Anti-TNF Recombinant Antibody (HPAB-0677-CN) ELISA, Neut Humanized IgG
HPAB-0678-CN Human Anti-TNF Recombinant Antibody (HPAB-0678-CN) ELISA, Neut Humanized IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-768 Afuco™ Anti-TNF ADCC Recombinant Antibody (Nerelimomab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody
AFC-TAB-006 Afuco™ Anti-TNF ADCC Recombinant Antibody (Infliximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-010 Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced FC, IP, ELISA, Neut, FuncS ADCC enhanced antibody
AFC-TAB-062 Afuco™ Anti-TNF ADCC Recombinant Antibody (Golimumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-1921-FY-F(E) Human Anti-TNF Recombinant Antibody (clone 9E7); scFv Fragment Inhib Human scFv
HPAB-1922-FY-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-1922-FY-F(E)) ELISA Human Fab
HPAB-1923-FY-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-1923-FY-F(E)) ELISA Human Fab
HPAB-1924-FY-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-1924-FY-F(E)) ELISA Human Fab
HPAB-1925-FY-F(E) Mouse Anti-TNF Recombinant Antibody (clone Mab32); scFv Fragment ELISA Mouse scFv

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