Mouse Anti-CD4 Recombinant Antibody (VS3-CJ268)

Name: Mouse Anti-CD4 Recombinant Antibody (VS3-CJ268)
SKU: VS3-CJ268
Rating: 5 (1 reviews)

CAT#: VS3-CJ268

This product is a mouse antibody that recognizes CD4.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4

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Specifications

Immunogen
Synthetic peptide

Host Species
Mouse

Type
Mouse IgG

Specificity
Human, Mouse and Rat CD4

Species Reactivity
Human, Mouse, Rat

Applications
ICC

Conjugate
Unconjugated

Product Property

Purification
Affinity chromatography

Purity
>95% as determined by SDS-PAGE

Buffer
50% Glycerol, PBS, pH7.4.

Preservative
0.02% sodium azide

Storage
Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Shipping
Ice packs

Applications

Application Notes
This antibody has been tested for use in Immunocytochemistry (1:50-1:200), Immunohistochemistry (1:200).

Target

Alternative Names
T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD_antigen: CD4; CD4mut

Gene ID
920

UniProt ID
P01730

Cellular Localization
Cell membrane, Membrane

Post Translation Modifications
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Phosphorylated by PKC; phosphorylation at Ser-433 plays an important role for CD4 internalization.

Protein Refseq
NP_000607.1

Function
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508).
Down-regulated by HIV-1 Vpu (PubMed:17346169).
Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).

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Related Diseases

Primary Immunodeficiency

Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS3-CJ268.pdf

MSDS

MSDS - VS3-CJ268.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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