Creative Biolabs is pleased to offer a comprehensive range of liposome-coupled antibody services to meet your specific research and therapeutic needs. Our lab is equipped with advanced techniques to customize liposome formulations. By combining the efficacy of liposomes with targeted antibodies, we can enhance the delivery and effectiveness of therapeutic agents in your projects.

Introduction

For certain molecules with extremely low immunogenicity, such as lipids, glycolipids, polysaccharides, and DNA, even when using carrier coupling methods to enhance their immunogenicity, it is often challenging to obtain highly specific antibodies against the target antigens. Therefore, when preparing antibodies for this type of antigen, it is crucial to identify an antigen delivery system that can effectively accommodate the specific characteristics of the antigen while efficiently delivering it to antigen-presenting cells (APCs).

Liposome carriers, known for their excellent antigen-stimulating activity, have emerged as a novel adjuvant or vaccine delivery system. The size, charge, and membrane components of liposomes can be easily and conveniently adjusted, giving them advantages not found in traditional protein carriers. This flexibility allows for the conversion of low or even non-immunogenic antigens into immunogenic ones, thereby increasing their opportunities for interaction with APCs and effective processing into actionable antigens. Importantly, liposomes are advantageous for vaccine development, as they are free from adverse side effects.

Creative Biolabs has leveraged its extensive research experience with liposomes to develop a comprehensive method for producing antibodies against low-immunogenicity antigens using liposomes as emulsifying carriers. We meticulously control the size of the liposomes to approximately 200 nm, a practice informed by valuable hands-on experience accumulated by our technical team during long-term projects.

Fig.1 Conventional Liposomes.^1,3

Services

Creative Biolabs offers surface coupling of antibodies to liposomes according to customer specifications, as well as testing the coupling rates. Moreover, we can customize liposomes to encapsulate various drugs and fluorescent molecules, along with a range of modifications. Our services include but not limited to:

• Antibody-PEGylated Liposomes: Improve circulation time and reduce immunogenicity, enhancing drug delivery efficiency.
• Antibody-Anionic Liposomes: Exhibit superior stability and compatibility with cationic biomolecules, making them ideal for targeted applications.
• Antibody-Cationic Liposomes: Enhance cellular uptake, allowing for improved delivery of therapeutics to target cells.
• Antibody-Long-circulating Liposomes: These are tailored for extended circulation in the bloodstream, maximizing therapeutic efficacy.
• Antibody-pH-sensitive Liposomes: Are designed to release their payload in response to pH changes, ensuring targeted delivery to specific environments, such as tumors.
• Antibody-Thermosensitive: Combine targeted drug delivery with immune modulation, providing potential for enhanced therapeutic outcomes.
• Antibody-Smart Liposomes: Utilize stimuli-responsive systems to release their contents in reaction to biological triggers, such as temperature or enzyme presence, ensuring precise therapeutic intervention.

Fig.2 Cellular Uptake Analysis of Antibody-PAR28-lipo And Antibody-PAR28-PEG.^2,3

Advantages

• Improved Stability: Liposomes can encapsulate antibodies, safeguarding them from degradation and enhancing their stability during storage and transport.
• Targeted Delivery: Liposomal formulations can be designed to enhance the specificity of antibody delivery to target cells, leading to improved therapeutic effects and reduced side effects.
• Improved Bioavailability: Liposomes can enhance the bioavailability of antibodies by facilitating their absorption and distribution in the body, making treatments more effective.
• Protection from Immunogenicity: Encapsulation in liposomes can help mask antibodies from the immune system, potentially reducing immunogenic responses.
• Versatility: Liposomal coupled antibody technology can be adapted for various applications, including cancer therapy, vaccine development, and diagnostic imaging.
• Reduced Toxicity: By targeting therapies more precisely to diseased tissues, this technology can minimize the toxicity associated with systemic administration of antibodies.
• Improved Efficacy: Combining antibodies with liposomes can enhance efficacy by improving cellular uptake and engagement with target cells.

At Creative Biolabs, our innovative service combines the targeting capabilities of antibodies with the delivery efficiency of liposomes, providing you with a powerful tool for your research and therapeutic applications. Please feel free to contact us for any inquiries or to discuss how we can assist you with our high-quality liposome-coupled antibody services.

For research use only. Not intended for any clinical use.