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    CD19 & CD28

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    Anti-CD19 & CD28 Products

    • Anti-CD19 (huB4)-SPDB-DM4 ADC (ADC-020LCT)
      • Target: CD19
      • Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
      • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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    • Anti-CD19 (clone B496)-SPP-DM1 ADC (ADC-181LZY)
      • Target: CD19
      • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-CD19 (clone B496)-MCC-DM1 ADC (ADC-182LZY)
      • Target: CD19
      • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-CD19 (clone huB4)-SMCC-DM1 ADC (ADC-157LZY)
      • Target: CD19
      • Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    For Research Use Only. Not For Clinical Use.


    Background

    Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
    CD19 & CD28
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular).
    CD19 & CD28
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