CD19 & CD28
This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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- Species Reactivity: Chicken, Turkey
- Type: Mouse Fab
- Application: FC
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- Derivation: Mouse
- Species Reactivity: canine
- Type: Mouse Fab
- Application: WB, ELISA, FuncS
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- Species Reactivity: Chicken, Turkey
- Type: Mouse scFv
- Application: FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized VH
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized VH
- Application: ELISA
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB, FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB
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- Species Reactivity: Human
- Type: scFv
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scfv
- Application: ELISA, WB, FC, IF
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- Species Reactivity: Human, Mouse
- Type: Human scFv
- Application: FC, Inhib, ADCC, FuncS
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- Species Reactivity: Human, Mouse
- Type: Human scFv
- Application: FC, Inhib, ADCC, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scfv
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scfv
- Application: FC, in vitro cytotoxic, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Humanized scfv
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Humanized scfv
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Humanized scfv
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, IHC, Block
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC, FuncS, ICC, IHC, IP, WB
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, IP, IF, FC
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- Species Reactivity: Human
- Type: Human scFv
- Application: WB, ELISA
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- Derivation: Hybridoma
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB
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- Derivation: Hybridoma
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Mouse IgG1 F(ab')2, κ
- Application: Agonist, Stim, Neu, FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, FuncS, ICC, IHC, IP, WB
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, IP, IF, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, in vitro cytotoxic, ELISA
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- Derivation: Human
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: FC
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FC, RIA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB
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- Species Reactivity: Human
- Type: Fab
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB, FC, IF
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Species Reactivity: Mouse
- Type: Mouse Fab
- Application: FC
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- Species Reactivity: Mouse
- Type: Mouse Fab
- Application: FC
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, FC
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- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: FC, Inhib, ADCC, FuncS
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- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: FC, Inhib, ADCC, FuncS
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: FC
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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- Species Reactivity: Human, Cynomolgus monkey
- Type: Human Fab
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus monkey
- Type: Humanized Fab
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus monkey
- Type: Humanized Fab
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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