Nimotuzumab Overview

Introduction of Nimotuzumab

Nimotuzumab is a humanized IgG1 monoclonal antibody (mAb) that as of 2014 had orphan status in the U.S. and European Union for glioma, and marketing approval in India, China, and other countries for squamous cell carcinomas of the head and neck (SCCHN), and was undergoing several clinical trials. It was developed at the Center of molecular immunology (CIM) in Havana, Cuba. Nimotuzumab binds to the epidermal growth factor receptor (EGFR), a signalling protein that normally controls cell division. Nimotuzumab was obtained by transplanting the complementarity determining regions (CDRs) of the murine IgG2a monoclonal ior egf/r3, to a human framework assisted by computer modeling. The parental murine monoclonal ior egf/r3 was generated by fusing the murine myeloma cells SP2/Ag14 with splenocytes from BALB/c mice immunized with a purified human placenta fraction enriched in EGFR and not with EGFR purified from cultured cells.

Mechanism of Action of Nimotuzumab

EGFR, also known as erb B1 or HER1, is a receptor tyrosine kinase (RTK) belonging, along with erb B2 (or HER 2), erb B3 and erb B4, to the RTK family of EGFR. When EGFR is bound to its ligand, dimerization occurs (homodimerizes with another EGFR or heterodimerizes with a different receptor of the same family) and a signaling cascade begins at intracellular level, activating, among others, the MAPK (mitogen-activated protein kinase), the STAT (signal transducer and activator of transcription) and the Akt antiapoptotic kinase pathways, different genes being eventually activated, and thus cellular response being produced. EGFR transmitted signal is inactivated by receptor internalization, and its degradation or recycling. EGFR is expressed in healthy tissue and in many tumors, particularly in those of epithelial origin, and its activation plays a significant role in tumorigenesis, by stimulating cell proliferation and inhibiting apoptosis. It also favors angiogenesis and facilitates metastasis generation. EGFR expression increase has been observed in many tumors. This EGFR overexpression usually correlates with a more advanced stage of the disease, a poorer prognosis and a worst response to chemotherapy. In preclinical models it was also found that the inhibition of these receptors had anti-tumour activity, and data available suggested synergy with chemotherapy as well as radiotherapy. Nimotuzumab binds with optimal affinity and high specificity to the extracellular region of EGFR, resulting in a blockade of ligand binding and receptor activation. In addition, as a IgG1 mAb, nimotuzumab could also be cytolytic on target tumors by its capacity to cause antibody dependent cell mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC).

Mechanism of action of NimotuzumabFig.1 Mechanism of action of nimotuzumab

Clinical Projects of Nimotuzumab*

NCT ID Status Conditions Lead Sponsor Update Time
NCT03554889 Not yet recruiting Advanced Cancer, ADCC, NK Cell Mediated Immunity, Nimotuzumab, Adaptive Transfer Hangzhou Cancer Hospital June 13, 2018
NCT02577341 Recruiting Non-small-cell Lung Cancer Sun Yat-sen University October 16, 2015
NCT00957086 Recruiting Carcinoma, Squamous Cell of Head and Neck National Cancer Centre, Singapore August 12, 2009
NCT02705612 Recruiting Cervical Cancer Fourth Military Medical University March 10, 2016
NCT02858206 Recruiting Esophageal Neoplasms Chinese Academy of Medical Sciences August 8, 2016
NCT03469531 Not yet recruiting Neoplasms, Cervical Adenosquamous Cell Carcinoma, Cervical Squamous Cell Carcinoma in Situ, Stage IB/IIA/IIB/III/IVA Cervical Cancer, Zhujiang Hospital March 19, 2018
NCT03557112 Recruiting Nasopharyngeal Carcinoma Guiyang Medical University June 14, 2018
NCT03400592 Recruiting Stomach Neoplasms Peking University January 17, 2018
NCT02947386 Recruiting EGFR Gene Mutation, Recurrent Non-Small Cell Lung Carcinoma, Stage IIIA/IIIB/IV Non-Small Cell Lung Cancer Roswell Park Cancer Institute October 27, 2016
NCT02672241 Recruiting Childhood Brain Stem Neoplasm Xinhua Hospital, Shanghai Jiao Tong University School of Medicine February 3, 2016
NCT03413579 Recruiting Cervical Cancer El Kendi Pharmaceuticals Manufacturing Company January 29, 2018
NCT02945267 Not yet recruiting Unresectable Pancreatic Cancer   October 26, 2016
NCT02611700 Recruiting Esophageal Squamous Cell Carcinomas Biotech Pharmaceutical Co., Ltd. November 23, 2015
NCT02428764 Recruiting Lung Cancer Sun Yat-sen University April 29, 2015
NCT02409186 Recruiting Prosthesis Survival Shandong Cancer Hospital and Institute April 6, 2015
NCT00702481 Active, not recruiting Head and Neck Cancer National Cancer Centre, Singapore June 20, 2008
NCT03025958 Recruiting Nasopharyngeal Carcinoma Zhejiang Cancer Hospital January 20, 2017

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Therapeutic Antibody

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Resources
* The table was excerpted from the following website
https://clinicaltrials.gov/ct2/results?cond=&term=Nimotuzumab

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